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    CG7322 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7322provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030968
    Locus tag
    Dmel_CG7322
    See related
    AllianceGenome:FB:FBgn0030968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7322
    Summary
    Predicted to enable L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Is expressed in adult head; adult heart; embryonic/larval fat body; and organism. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7322 in Genome Data Viewer
    Location:
    17E1-17E1; 1-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18855873..18857757, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18749906..18751790, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene PDGF- and VEGF-related factor 1 Neighboring gene hat-trick Neighboring gene shopper Neighboring gene Ubiquitin specific protease 39 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Otto N, et al. Nat Commun, 2018 Aug 29. PMID 30158546, Free PMC Article
    2. Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge. Alias Z, et al. Proteomics, 2007 Oct. PMID 17907271
    3. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Yoon WH, et al. Neuron, 2017 Jan 4. PMID 28017472, Free PMC Article
    4. Drosophila glia: Few cell types and many conserved functions. Yildirim K, et al. Glia, 2019 Jan. PMID 30443934
    5. A cross-species approach for the identification of Drosophila male sterility genes. Ibaraki K, et al. G3 (Bethesda), 2021 Aug 7. PMID 34849808, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-xylulose reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7322-PA
    CG7322-PB
    CG7322-PC
    NP_001259693.1
    NP_001285416.1
    NP_573333.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18855873..18857757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133105.3 → NP_573333.2  uncharacterized protein Dmel_CG7322, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573333.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA6, Q9VWP2
      Related
      FBpp0074425
      Conserved Domains (1) summary
      cd05351
      Location:1 → 242
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    2. NM_001298487.1 → NP_001285416.1  uncharacterized protein Dmel_CG7322, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA6, Q9VWP2
      Conserved Domains (1) summary
      cd05351
      Location:1 → 242
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

    3. NM_001272764.1 → NP_001259693.1  uncharacterized protein Dmel_CG7322, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYA6, Q9VWP2
      Conserved Domains (1) summary
      cd05351
      Location:1 → 242
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYA6 Q8SYA6
    Q9VWP2 Q9VWP2

    Gene LinkOut

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