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    CG4259 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4259provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031389
    Locus tag
    Dmel_CG4259
    See related
    AllianceGenome:FB:FBgn0031389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4259; SPH173
    Summary
    Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4259 in Genome Data Viewer
    Location:
    22C3-22C3; 2-4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2127309..2129237, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2127309..2129237, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 3 Neighboring gene long non-coding RNA:CR44808 Neighboring gene long non-coding RNA:CR44055 Neighboring gene Glycogen phosphorylase Neighboring gene tho2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Chen S, et al. Fly (Austin), 2011 Oct-Dec. PMID 21946255, Free PMC Article
    2. Generating customized transgene landing sites and multi-transgene arrays in Drosophila using phiC31 integrase. Knapp JM, et al. Genetics, 2015 Apr. PMID 25680812, Free PMC Article
    3. Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis. Okumura M, et al. J Neurosci, 2015 Feb 4. PMID 25653356, Free PMC Article
    4. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Chen S, et al. Cell Rep, 2012 Feb 23. PMID 22832161, Free PMC Article
    5. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. Castillo DM, et al. BMC Evol Biol, 2011 Sep 14. PMID 21917173, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slfc has a role in survival and reproduction. [review]
      Title: Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4259-PA
    CG4259-PB

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2127309..2129237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272975.2 → NP_001259904.1  uncharacterized protein Dmel_CG4259, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ75
      Conserved Domains (2) summary
      smart00020
      Location:39 → 256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:39 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_134801.2 → NP_608645.1  uncharacterized protein Dmel_CG4259, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ75
      Related
      FBpp0077526
      Conserved Domains (2) summary
      smart00020
      Location:39 → 256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:39 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ75 Q9VQ75

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