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    insv insensitive [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    insvprovided by FlyBase
    Official Full Name
    insensitiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031434
    Locus tag
    Dmel_CG3227
    See related
    AllianceGenome:FB:FBgn0031434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE55538; CG3227; Dmel\CG3227; Insv
    Summary
    Enables chromatin insulator sequence binding activity; sequence-specific DNA binding activity; and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of Notch signaling pathway. Located in nucleus. Is expressed in several structures, including CNS glial cell; antennal anlage; antennal primordium; external sensory organ precursor cell; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See insv in Genome Data Viewer
    Location:
    23A1-23A1; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2575280..2576997, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2575280..2576997, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 309a2 Neighboring gene Radiation insensitive 1 Neighboring gene SWIM domain containing Srs2 interacting protein 1 Neighboring gene Early boundary activity 2 Neighboring gene NADH dehydrogenase (ubiquinone) B17.2 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BEN: a novel domain in chromatin factors and DNA viral proteins. Abhiman S, et al. Bioinformatics, 2008 Feb 15. PMID 18203771, Free PMC Article
    2. MicroRNA mediated regulation of the onset of enteroblast differentiation in the Drosophila adult intestine. Mukherjee S, et al. Cell Rep, 2022 Oct 18. PMID 36261011, Free PMC Article
    3. Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Fab-8 Boundary. Kyrchanova O, et al. Genetics, 2019 Nov. PMID 31551239, Free PMC Article
    4. Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive. Fedotova A, et al. Epigenetics Chromatin, 2019 Jan 3. PMID 30602385, Free PMC Article
    5. BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo. Xu N, et al. Sci Rep, 2016 Sep 30. PMID 27687115, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insv can assemble into a multivalent DNA-binding complex and the N-terminal Insv multimerization domain is critical for boundary function.
      Title: Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive.
    2. Insv protein is required for Fab-7 boundary function and establishment of segmental identity.
      Title: The BEN Domain Protein Insensitive Binds to the Fab-7 Chromatin Boundary To Establish Proper Segmental Identity in Drosophila.
    3. These data shed first light on the in vivo function for a BEN-solo protein, Insv, as an Su(H) corepressor in the Notch pathway regulating neural development.
      Title: Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin insulator sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insensitive
    Names
    CG3227-PA
    CG3227-PB
    insv-PA
    insv-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2575280..2576997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134846.3 → NP_608690.2  insensitive, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608690.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK5, Q9VQD5
      Related
      FBpp0077426
      Conserved Domains (1) summary
      smart01025
      Location:278 → 356
      BEN; The BEN domain is found in diverse animal proteins

    2. NM_001298637.1 → NP_001285566.1  insensitive, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYK5, Q9VQD5
      Conserved Domains (1) summary
      smart01025
      Location:278 → 356
      BEN; The BEN domain is found in diverse animal proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYK5.2 Q8SYK5

    Gene LinkOut

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