HP6 Heterochromatin protein 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: HP6provided by FlyBase
Official Full Name: Heterochromatin protein 6provided by FlyBase
Primary source: FLYBASE:FBgn0031613
Locus tag: Dmel_CG15636
See related: AllianceGenome:FB:FBgn0031613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15636; Dmel\CG15636; UMB; umbrea; Umbrea; UMBREA
Summary: Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in female meiotic nuclear division and telomere capping. Located in chromocenter; chromosome; and nucleolus. Is expressed in organism and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4577719..4578218, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4577719..4578218, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare.
Title: HP6/Umbrea is dispensable for viability and fertility, suggesting essentiality of newly evolved genes is rare.
results indicate that DREF directly regulates expression of the HP6 gene.
Title: Genetic screening for modifiers of the DREF pathway in Drosophila melanogaster: identification and characterization of HP6 as a novel target of DREF.
these results suggest that Umbrea cooperates with Hip, HP1 and HOAP and plays a functional role in mediating normal telomere behaviour in Drosophila.
Title: Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info

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