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    CG13133 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13133provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032181
    Locus tag
    Dmel_CG13133
    See related
    AllianceGenome:FB:FBgn0032181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel24.5; Dmel\CG13133
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding; protein refolding; and response to heat. Predicted to be active in cytoplasm and nucleus. Is expressed in Johnston organ. Human ortholog(s) of this gene implicated in cataract 16 multiple types; cataract 9 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAA (crystallin alpha A) and CRYAB (crystallin alpha B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13133 in Genome Data Viewer
    Location:
    31A2-31A2; 2-39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10091208..10092389, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10091208..10092389, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Serpin 31A Neighboring gene Pendulin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila small heat shock proteins: cell and organelle-specific chaperones? Michaud S, et al. Prog Mol Subcell Biol, 2002. PMID 11908067
    2. Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Vos MJ, et al. Aging Cell, 2016 Apr. PMID 26705243, Free PMC Article
    3. The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. Li ZW, et al. BMC Evol Biol, 2009 Aug 28. PMID 19715580, Free PMC Article
    4. Developmental Expression and Functions of the Small Heat Shock Proteins in Drosophila. Jagla T, et al. Int J Mol Sci, 2018 Nov 2. PMID 30400176, Free PMC Article
    5. MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging. Kennerdell JR, et al. Nat Commun, 2018 Oct 10. PMID 30305625, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13133-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10091208..10092389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135499.3 → NP_609343.1  uncharacterized protein Dmel_CG13133 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL41
      Related
      FBpp0079559
      Conserved Domains (1) summary
      cd06526
      Location:87 → 163
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL41 Q9VL41

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