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    Pkd2 Polycystic kidney disease 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34651, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pkd2provided by FlyBase
    Official Full Name
    Polycystic kidney disease 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0041195
    Locus tag
    Dmel_CG6504
    See related
    AllianceGenome:FB:FBgn0041195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    amo; Amo; AMO; CG6504; Dmel\CG6504; Dmpkd2; pkd2; PKD2; TRPP; TRPP2
    Summary
    Predicted to enable calcium channel activity. Involved in several processes, including flagellated sperm motility; larval feeding behavior; and sperm storage. Located in sperm flagellum. Is expressed in adult head and spermatozoon. Used to study autosomal dominant polycystic kidney disease and polycystic kidney disease 2. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; polycystic kidney disease; polycystic kidney disease 2; and retinal degeneration. Orthologous to human PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel); PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel); and PKD2 (polycystin 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pkd2 in Genome Data Viewer
    Location:
    33E3-33E3; 2-46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12398274..12402023)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12398274..12402023)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bruno 2 Neighboring gene uncharacterized protein Neighboring gene virus-induced RNA 1 Neighboring gene Fam92

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel. Venglarik CJ, et al. J Am Soc Nephrol, 2004 May. PMID 15100357
    2. Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Hofherr A, et al. Kidney Int, 2016 Apr. PMID 26924047, Free PMC Article
    3. Transient receptor potential polycystin-2 (TRPP2) regulates motility and intracellular calcium of porcine sperm. Daigneault BW, et al. Andrologia, 2021 Sep. PMID 34042198
    4. Parallel Evolution of Sperm Hyper-Activation Ca2+ Channels. Cooper JC, et al. Genome Biol Evol, 2017 Jul 1. PMID 28810709, Free PMC Article
    5. PKD2 cation channel is required for directional sperm movement and male fertility. Gao Z, et al. Curr Biol, 2003 Dec 16. PMID 14680633

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transient receptor potential polycystin-2 (TRPP2) regulates motility and intracellular calcium of porcine sperm.
      Title: Transient receptor potential polycystin-2 (TRPP2) regulates motility and intracellular calcium of porcine sperm.
    2. A targeted mutation in this gene caused nearly complete male sterility
      Title: A flagellar polycystin-2 homolog required for male fertility in Drosophila.
    3. expression of DmPKD2 in Drosophila S2 cells produced a novel channel.
      Title: Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel.
    4. PKD2 cooperates with the ryanodine receptor to promote optimal muscle contractility through intracellular Ca(2+) homeostasis.
      Title: Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm competition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of polycystin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycystic kidney disease 2
    Names
    CG6504-PA
    Pkd2-PA
    almost there
    polycystic kidney disease 2 ortholog
    polycystic kidney disease gene-2
    polycystin-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12398274..12402023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135717.3 → NP_609561.2  polycystic kidney disease 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609561.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6T3S5, Q6WIZ8, Q9VK95
      Conserved Domains (1) summary
      pfam08016
      Location:402 → 803
      PKD_channel; Polycystin cation channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T3S5 Q6T3S5
    Q9VK95 Q9VK95

    Gene LinkOut

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