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    Mgstl Microsomal glutathione S-transferase-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgstlprovided by FlyBase
    Official Full Name
    Microsomal glutathione S-transferase-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025814
    Locus tag
    Dmel_CG1742
    See related
    AllianceGenome:FB:FBgn0025814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE10696; BcDNA:RH59553; CG1742; Dmel\CG1742; Mgst1
    Summary
    Predicted to enable glutathione peroxidase activity; glutathione transferase activity; and prostaglandin-E synthase activity. Predicted to be located in mitochondrial outer membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; germline cell; gut section; and larval antenno-maxillary sensory complex. Orthologous to several human genes including MGST1 (microsomal glutathione S-transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mgstl in Genome Data Viewer
    Location:
    19E7-19E7; 1-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21042125..21044107)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20913152..20915134)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nuclear transport factor-2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44431 Neighboring gene Cystathionine beta-synthase Neighboring gene ncRNA Neighboring gene Catalytic subunit 3A of the oligosaccharyltransferase complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic and enzymatic characterization of the MAPEG superfamily. Bresell A, et al. FEBS J, 2005 Apr. PMID 15794756
    2. Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster. Toba G, et al. Gene, 2000 Aug 8. PMID 10940555
    3. Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration. Mellentine SQ, et al. Front Cell Dev Biol, 2023. PMID 38283991, Free PMC Article
    4. GAL4 enhancer trap patterns during Drosophila development. Ward EJ, et al. Genesis, 2002 Sep-Oct. PMID 12324946
    5. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    microsomal glutathione S-transferase-like
    Names
    CG1742-PA
    CG1742-PB
    CG1742-PC
    Mgstl-PA
    Mgstl-PB
    Mgstl-PC
    microsomal glutathione
    microsomal glutathione transferase 1
    transferase
    NP_001285507.1
    NP_524696.2
    NP_728382.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21042125..21044107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298578.1 → NP_001285507.1  microsomal glutathione S-transferase-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY70
      Conserved Domains (1) summary
      pfam01124
      Location:17 → 147
      MAPEG; MAPEG family

    2. NM_167724.3 → NP_728382.1  microsomal glutathione S-transferase-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY70
      Related
      FBpp0076935
      Conserved Domains (1) summary
      pfam01124
      Location:17 → 147
      MAPEG; MAPEG family

    3. NM_079957.4 → NP_524696.2  microsomal glutathione S-transferase-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524696.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97471, Q8SY19, Q9VRD8
      Related
      FBpp0076936
      Conserved Domains (1) summary
      pfam01124
      Location:20 → 148
      MAPEG; MAPEG family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97471 O97471
    Q8SY19 Q8SY19
    Q8SY70 Q8SY70

    Gene LinkOut

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