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    COX4L Cytochrome c oxidase subunit 4-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX4Lprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 4-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033020
    Locus tag
    Dmel_CG10396
    See related
    AllianceGenome:FB:FBgn0033020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT07685; CG10396; COX IV; cox4; COXIV; CX41; CX42; Dmel\CG10396; IV
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX4L in Genome Data Viewer
    Location:
    41E5-41E5; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5353994..5354723)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1241499..1242228)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 20 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COX4-like, a Nuclear-Encoded Mitochondrial Gene Duplicate, Is Essential for Male Fertility in Drosophila melanogaster. Eslamieh M, et al. Genes (Basel), 2022 Feb 25. PMID 35327978, Free PMC Article
    2. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
    3. State of Drosophila melanogaster Ovaries after a Full Cycle of Gametogenesis under Microgravity Modeling: Cellular Respiration and the Content of Cytoskeletal Proteins. Usik MA, et al. Int J Mol Sci, 2021 Aug 26. PMID 34502148, Free PMC Article
    4. Mitochondrial Respiration in Drosophila Ovaries after a Full Cycle of Oogenesis under Simulated Microgravity. Ogneva IV, et al. Curr Issues Mol Biol, 2021 May 22. PMID 34067415, Free PMC Article
    5. Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration. Ogneva IV, et al. Int J Mol Sci, 2020 Aug 20. PMID 32825268, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 4-like
    Names
    CG10396-PA
    CG10396-PB
    COX4L-PA
    COX4L-PB
    c oxidase
    cytochrome
    cytochrome c oxidase
    cytochrome c oxidase subunit IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5353994..5354723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273779.1 → NP_001260708.1  cytochrome c oxidase subunit 4-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEI0
      Conserved Domains (1) summary
      pfam02936
      Location:31 → 162
      COX4; Cytochrome c oxidase subunit IV

    2. NM_136324.4 → NP_610168.1  cytochrome c oxidase subunit 4-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4H8, Q9V9F6
      Related
      FBpp0085425
      Conserved Domains (1) summary
      pfam02936
      Location:45 → 176
      COX4; Cytochrome c oxidase subunit IV
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEI0 A0A0B4KEI0
    Q8T4H8 Q8T4H8

    Gene LinkOut

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