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    Tsp42Ef Tetraspanin 42Ef [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Efprovided by FlyBase
    Official Full Name
    Tetraspanin 42Efprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033127
    Locus tag
    Dmel_CG12845
    See related
    AllianceGenome:FB:FBgn0033127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12845; Dm.Tsp42Ef; Dmel\CG12845
    Summary
    Involved in determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; ganglia; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42Ef in Genome Data Viewer
    Location:
    42E5-42E5; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7025010..7028082)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2912515..2915587)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44172 Neighboring gene Tetraspanin 42Eg Neighboring gene Tetraspanin 42Eh

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active Wnt proteins are secreted on exosomes. Gross JC, et al. Nat Cell Biol, 2012 Oct. PMID 22983114
    2. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Harbison ST, et al. Nat Genet, 2009 Mar. PMID 19234472, Free PMC Article
    3. Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Beckett K, et al. Traffic, 2013 Jan. PMID 23035643, Free PMC Article
    4. Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2. Kwon Y, et al. Dev Cell, 2015 Apr 6. PMID 25850671, Free PMC Article
    5. Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO. Kwon SY, et al. Life Sci Alliance, 2020 Feb. PMID 31992650, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42Ef
    Names
    CG12845-PA
    Tsp42Ef-PA
    tetraspanin 42E
    tetraspanin42Ef

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7025010..7028082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078908.3 → NP_523632.2  tetraspanin 42Ef [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523632.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K010
      Related
      FBpp0088094
      Conserved Domains (2) summary
      cd03127
      Location:103 → 181
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:7 → 211
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K010 Q7K010

    Gene LinkOut

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