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    kappaTry kappaTry [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kappaTryprovided by FlyBase
    Official Full Name
    kappaTryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043471
    Locus tag
    Dmel_CG12388
    See related
    AllianceGenome:FB:FBgn0043471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12388; Dmel\CG12388; KappaTry; SPH109
    Summary
    Predicted to be involved in proteolysis. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
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    Try the new Transcript table

    Genomic context

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    See kappaTry in Genome Data Viewer
    Location:
    47F3-47F3; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11337797..11338733, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7225302..7226238, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene shavenoid Neighboring gene lambdaTry Neighboring gene zetaTrypsin Neighboring gene etaTrypsin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study on the material basis and mechanism of Hemerocallis citrina Baroni on sleep-improvement using Drosophila activity monitoring, metabolomic, targeted screening and transcriptomic. Liang Y, et al. Food Res Int, 2023 Oct. PMID 37689837
    2. I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells. Buddika K, et al. Development, 2021 Jan 7. PMID 33246929, Free PMC Article
    3. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
    4. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    5. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables serine-type endopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kappaTry
    Names
    CG12388-PC
    kappaTry-PC

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11337797..11338733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136830.7 → NP_610674.5  kappaTry [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610674.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8J7, Q9GP27
      Conserved Domains (2) summary
      smart00020
      Location:25 → 253
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:26 → 256
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8J7 A1Z8J7
    Q9GP27 Q9GP27

    Gene LinkOut

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