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    knon knotted onions [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    knonprovided by FlyBase
    Official Full Name
    knotted onionsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285943
    Locus tag
    Dmel_CG7813
    See related
    AllianceGenome:FB:FBgn0285943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7813; Dmel\CG7813; ms(2)1400
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in Nebenkern assembly. Part of proton-transporting ATP synthase complex. Is expressed in adult head; primary spermatocyte; secondary spermatocyte; spermatid cyst; and spermatozoon. Orthologous to human ATP5PD (ATP synthase peripheral stalk subunit d). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See knon in Genome Data Viewer
    Location:
    53C6-53C6; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16496889..16499429, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12384394..12386934, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 8 Neighboring gene Semaphorin 2a Neighboring gene loopin-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons. Morton DJ, et al. PLoS Genet, 2020 Jul. PMID 32645003, Free PMC Article
    2. Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila. Sawyer EM, et al. BMC Cell Biol, 2017 Mar 23. PMID 28335714, Free PMC Article
    3. Mitochondrial Differentiation during Spermatogenesis: Lessons from Drosophila melanogaster. Vedelek V, et al. Int J Mol Sci, 2024 Apr 3. PMID 38612789, Free PMC Article
    4. Mitochondrial Control of Stem Cell State and Fate: Lessons From Drosophila. Tiwari SK, et al. Front Cell Dev Biol, 2021. PMID 34012959, Free PMC Article
    5. Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. Mikhaylova LM, et al. BMC Biol, 2011 May 4. PMID 21542906, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Nebenkern assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase, stator stalk ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    knotted onions
    Names
    CG7813-PA
    knon-PA
    ms(2)1400

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16496889..16499429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137289.1 → NP_611133.1  knotted onions [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAH1, Q8MSH2
      Related
      FBpp0086272, FBtr0087126
      Conserved Domains (1) summary
      pfam05873
      Location:26 → 184
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAH1 A1ZAH1
    Q8MSH2 Q8MSH2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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