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    asrij asrij [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asrijprovided by FlyBase
    Official Full Name
    asrijprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034793
    Locus tag
    Dmel_CG13533
    See related
    AllianceGenome:FB:FBgn0034793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    arj; Asrij; CG13533; Dmasrij; Dmel\CG13533; FBgn 34793
    Summary
    Involved in several processes, including hematopoietic stem cell homeostasis; positive regulation of receptor signaling pathway via JAK-STAT; and regulation of antibacterial peptide production. Acts upstream of with a negative effect on lymph gland crystal cell differentiation. Located in Golgi apparatus; endosome; and lysosome. Is active in mitochondrion. Is expressed in several structures, including adult head; amnioserosa primordium; embryonic/larval lymph gland; epithelium; and hemocyte. Orthologous to several human genes including OCIAD1 (OCIA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See asrij in Genome Data Viewer
    Location:
    59B4-59B4; 2-101 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22886398..22887578)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18773921..18775101)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-phosphate 5-kinase 59B Neighboring gene ER membrane protein complex subunit 8/9 Neighboring gene YME1 like ATPase Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase Neighboring gene Mediator complex subunit 23 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The OCIAD protein family: comparative developmental biology and stem cell application. Praveen W, et al. Int J Dev Biol, 2020. PMID 32659010
    2. Expression, Purification and Crystallization of Asrij, A Novel Scaffold Transmembrane Protein. Motiwala Z, et al. J Membr Biol, 2021 Feb. PMID 33433647
    3. A Conserved Role for Asrij/OCIAD1 in Progenitor Differentiation and Lineage Specification Through Functional Interaction With the Regulators of Mitochondrial Dynamics. Ray A, et al. Front Cell Dev Biol, 2021. PMID 34295888, Free PMC Article
    4. Drosophila asrij is expressed in pole cells, trachea and hemocytes. Inamdar MS. Dev Genes Evol, 2003 Apr. PMID 12690451
    5. Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis. Khadilkar RJ, et al. Sci Rep, 2017 Mar 8. PMID 28273919, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the lymph gland proteome were analyzedunder genetic conditions that either maintain precursors or promote their differentiation in vivo, by perturbing expression of Asrij, a conserved endosomal regulator of hematopoiesis.
      Title: Proteomics of Asrij Perturbation in Drosophila Lymph Glands for Identification of New Regulators of Hematopoiesis.
    2. Results show that in addition to its requirement in hematopoiesis, the ARF1-Asrij axis can differentially regulate humoral immunity in Drosophila, most likely by virtue of its endosomal function. ARF1 and Asrij bring about differential endocytic modulation of immune pathways and their depletion leads to aberrant pathway activity and an immune imbalance.
      Title: Differential modulation of the cellular and humoral immune responses in Drosophila is mediated by the endosomal ARF1-Asrij axis.
    3. ARF1-Asrij endocytic axis modulates signals that govern hematopoietic development.
      Title: ARF1-GTP regulates Asrij to provide endocytic control of Drosophila blood cell homeostasis.
    4. a role for Asrij in causing increased Notch signaling thereby affecting hemocyte differentiation
      Title: Asrij maintains the stem cell niche and controls differentiation during Drosophila lymph gland hematopoiesis.
    5. Drosophila asrij functions in the hematopoietic lineage
      Title: Drosophila asrij is expressed in pole cells, trachea and hemocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in embryonic hemopoiesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hematopoietic stem cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect lymph gland crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of antibacterial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asrij
    Names
    CG13533-PA
    CG13533-PB
    asrij-PA
    asrij-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22886398..22887578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137889.3 → NP_611733.1  asrij, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611733.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W1X9
      Related
      FBpp0071813
      Conserved Domains (1) summary
      pfam07051
      Location:21 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)

    2. NM_001274214.1 → NP_001261143.1  asrij, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF31
      Conserved Domains (1) summary
      pfam07051
      Location:21 → 109
      OCIA; Ovarian carcinoma immunoreactive antigen (OCIA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF31 A0A0B4KF31
    Q9W1X9.1 Q9W1X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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