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    levy levy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37728, updated on 9-Dec-2024

    Summary

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    Official Symbol
    levyprovided by FlyBase
    Official Full Name
    levyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034877
    Locus tag
    Dmel_CG17280
    See related
    AllianceGenome:FB:FBgn0034877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH03295; CG17280; Cox6a; COX6A; COXD; COXE; Dmel\CG17280; Levy; VIa
    Summary
    Enables enzyme regulator activity. Involved in determination of adult lifespan and mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Used to study cytochrome-c oxidase deficiency disease and mitochondrial encephalomyopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate D and mitochondrial complex IV deficiency nuclear type 18. Orthologous to several human genes including COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See levy in Genome Data Viewer
    Location:
    59E3-59E3; 2-103 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23548239..23548982)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19435762..19436505)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 59f Neighboring gene aaRS-interacting multifunctional protein 3 Neighboring gene wing morphogenesis defect Neighboring gene pita Neighboring gene Death caspase-1 Neighboring gene Rrp4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies. Graham C, et al. Geroscience, 2022 Aug. PMID 35355221, Free PMC Article
    2. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Liu W, et al. Genetics, 2007 Jun. PMID 17435251, Free PMC Article
    3. Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. Brown AE, et al. PLoS One, 2009. PMID 19221590, Free PMC Article
    4. Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics. Borchardt LA, et al. Int J Mol Sci, 2023 Jan 17. PMID 36768163, Free PMC Article
    5. Sequence elements in cis influence heterochromatic silencing in trans. Sage BT, et al. Mol Cell Biol, 2005 Jan. PMID 15601858, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    levy
    Names
    CG17280-PA
    CG17280-PB
    cytochrome c oxidase VIa
    cytochrome c oxidase polypeptide VIA
    cytochrome c oxidase subunit 6A
    levy-PA
    levy-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23548239..23548982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137961.3 → NP_611805.1  levy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1N3
      Related
      FBpp0071970
      Conserved Domains (1) summary
      cd00925
      Location:24 → 108
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001299841.1 → NP_001286770.1  levy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1N3
      Conserved Domains (1) summary
      cd00925
      Location:24 → 108
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1N3 Q9W1N3

    Gene LinkOut

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