SiaT Sialyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SiaTprovided by FlyBase
Official Full Name: Sialyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035050
Locus tag: Dmel_CG4871
See related: AllianceGenome:FB:FBgn0035050
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4871; D.SialT; D.SiaT; Dm ST; Dmel\CG4871; DmPST; DmSialT; dSiaT; DSiaT; dST6Gal I; SialT; ST; St6Gal; ST6Gal; ST6GAL
Summary: Enables beta-galactoside alpha-2,6-sialyltransferase activity. Involved in neuromuscular junction development; oligosaccharide metabolic process; and protein glycosylation. Located in Golgi apparatus and extracellular region. Is expressed in organism and presumptive embryonic salivary gland. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1) and ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60D14-60D14; 2-107 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24691422..24694386, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20578945..20581909, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DSiaT mutations result in decreased life span, locomotor abnormalities, temperature-sensitive paralysis, and defects of neuromuscular junctions. DSiaT regulates neuronal excitability and affects function of a voltage-gated sodium channel.
Title: Sialyltransferase regulates nervous system function in Drosophila.
This gene encodes a functional alpha2-6-sialyltransferase (SiaT) that is closely related to the vertebrate ST6Gal sialyltransferase family, indicating an ancient evolutionary origin for this family.
Title: Functional characterization of Drosophila sialyltransferase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside alpha-2,6-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sialylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sialyltransferase

Names: CG4871-PA; CG4871-PB; SiaT-PA; SiaT-PB; alpha-2,6-sialyltransferase; alpha2,6-sialyltransferase; b-galactoside-a-2,6-sialyltransferase; sialyltransferase-like

NP_523853.1

EC 2.4.3.-

EC 2.4.3.1

NP_726474.1

EC 2.4.3.-

EC 2.4.3.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24691422..24694386 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166684.2 → NP_726474.1 sialyltransferase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726474.1

Status: REVIEWED

UniProtKB/TrEMBL

Q29QZ9, Q9W121

Related

FBpp0072347

Conserved Domains (1) summary

pfam00777
Location:201 → 414

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
NM_079129.3 → NP_523853.1 sialyltransferase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523853.1

Status: REVIEWED

UniProtKB/TrEMBL

Q29QZ9, Q9GU23

Related

FBpp0072346

Conserved Domains (1) summary

pfam00777
Location:224 → 437

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)