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    Mul1 Mitochondrial E3 ubiquitin protein ligase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38472, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mul1provided by FlyBase
    Official Full Name
    Mitochondrial E3 ubiquitin protein ligase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035483
    Locus tag
    Dmel_CG1134
    See related
    AllianceGenome:FB:FBgn0035483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1134; Dmel\CG1134; mul1; MUL1
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of mitochondrial fission and protein ubiquitination. Predicted to be located in mitochondrial outer membrane and peroxisome. Is expressed in adult head; anlage in statu nascendi; hindgut anlage in statu nascendi; organism; and spermatozoon. Used to study Parkinson's disease. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mul1 in Genome Data Viewer
    Location:
    64A4-64A4; 3-10 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4021457..4023501)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4021457..4023058)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Forkhead box L1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 64a Neighboring gene Gustatory receptor 64c Neighboring gene Gustatory receptor 64b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models. Doktór B, et al. BMC Neurosci, 2019 May 28. PMID 31138137, Free PMC Article
    2. Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Zhang T, et al. Elife, 2017 Mar 21. PMID 28322724, Free PMC Article
    3. Drosophila FoxL1 non-autonomously coordinates organ placement during embryonic development. Hanlon CD, et al. Dev Biol, 2016 Nov 15. PMID 27618755, Free PMC Article
    4. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
    5. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Tsai PI, et al. Mol Cell, 2018 Mar 1. PMID 29456190

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. changes observed in the brains of these Drosophila models of Parkinson's Disease, in which mitochondrial ligases MUL1 and PARKIN do not function, may explain the mechanisms of some neurological and behavioural symptoms of PD.
      Title: Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson's disease models.
    2. MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin to maintain mitochondrial integrity.
      Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial E3 ubiquitin protein ligase 1
    Names
    CG1134-PA
    CG1134-PB
    Mul1-PA
    Mul1-PB
    mitochondrial E3 ubiquitin protein ligase 1 homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4021457..4023501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316436.1 → NP_001303365.1  mitochondrial E3 ubiquitin protein ligase 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZJ9
      Conserved Domains (3) summary
      pfam12483
      Location:89 → 243
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:286 → 329
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd16787
      Location:290 → 325
      mRING-HC-C3HC5_CGRF1; modified RING-HC finger (C3HC5-type) [structural motif]

    2. NM_139590.4 → NP_647847.1  mitochondrial E3 ubiquitin protein ligase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZJ9
      Related
      FBpp0073049
      Conserved Domains (3) summary
      pfam12483
      Location:89 → 243
      GIDE; E3 Ubiquitin ligase
      pfam13920
      Location:286 → 329
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd16787
      Location:290 → 325
      mRING-HC-C3HC5_CGRF1; modified RING-HC finger (C3HC5-type) [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZJ9.1 Q9VZJ9

    Gene LinkOut

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