Tcs5 Threonyl-carbamoyl synthesis 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tcs5provided by FlyBase
Official Full Name: Threonyl-carbamoyl synthesis 5provided by FlyBase
Primary source: FLYBASE:FBgn0035590
Locus tag: Dmel_CG10673
See related: AllianceGenome:FB:FBgn0035590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10673; Dm bud32; Dmel\CG10673; dPrpk; Prpk; tcs5
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in positive regulation of TOR signaling and positive regulation of cell growth. Located in cytoplasm. Is expressed in eye-antennal disc; imaginal disc; and organism. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 4. Orthologous to human TP53RK (TP53 regulating kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5138652..5139395, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5131752..5132495, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA threonylcarbamoyladenosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of EKC/KEOPS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

Names: CG10673-PA; Tcs5-PA; p53-related protein kinase; p53-related protein kinase ortholog; tRNA adenosine(37) threonylcarbamoyltransferase complex, ATPase subunit type 2

NP_647948.1

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The following sections contain reference sequences that belong to a specific genome build. Explain