U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG8209 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38888, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG8209provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035830
    Locus tag
    Dmel_CG8209
    See related
    AllianceGenome:FB:FBgn0035830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.138; Dmel\CG8209
    Summary
    Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein K48-linked deubiquitination; and negative regulation of protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; ganglia; germline cell; and gonad. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG8209 in Genome Data Viewer
    Location:
    66A21-66A21; 3-21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7976406..7977849)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7969506..7970949)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease X25 Neighboring gene uncharacterized protein Neighboring gene Heterochromatin protein 4 Neighboring gene POP4 ribonuclease P/MRP subunit Neighboring gene nemo Neighboring gene transfer RNA:Alanine-AGC 2-1 Neighboring gene antisense RNA:CR45867 Neighboring gene bip1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162556, Free PMC Article
    2. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    3. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. Bilen J, et al. PLoS Genet, 2007 Oct. PMID 17953484, Free PMC Article
    4. The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy. Pai YL, et al. Cell Death Dis, 2023 Aug 22. PMID 37607937, Free PMC Article
    5. Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Lee SY, et al. Cell Mol Life Sci, 2014 Jul. PMID 24292889, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein K48-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG8209-PA
    UBA/UBX 33.3 kDa protein like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7976406..7977849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139910.4 → NP_648167.1  uncharacterized protein Dmel_CG8209 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYN6, Q9VSC5
      Related
      FBpp0076470
      Conserved Domains (2) summary
      cd01772
      Location:250 → 328
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:2 → 42
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYN6 Q8SYN6
    Q9VSC5 Q9VSC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous