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    Sarm Sterile alpha and Armadillo motif [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sarmprovided by FlyBase
    Official Full Name
    Sterile alpha and Armadillo motifprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262579
    Locus tag
    Dmel_CG43119
    See related
    AllianceGenome:FB:FBgn0262579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.272; CG13680; CG13681; CG34373; CG43119; CG7905; CG7915; circRNA Edis; circ_1705; circ_Ect4; Dmel\CG43119; dsarm; dSarm; dSARM; dSarm1; dSARM1; ect4; Ect4; ECT4; Ect4/SARM; Edis; sarm; SARM; SARM1
    Old locus tag
    CG13680; CG7915; Dmel_CG13680; Dmel_CG13681; Dmel_CG34373; Dmel_CG7915
    Summary
    Enables NAD+ nucleosidase activity and STAT family protein binding activity. Involved in several processes, including NAD catabolic process; antiviral innate immune response; and positive regulation of receptor signaling pathway via STAT. Located in cytosol; neuron projection; and neuronal cell body. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and head epidermis primordium. Used to study neurodegenerative disease. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sarm in Genome Data Viewer
    Location:
    66B4-66B6; 3-22 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8063874..8108897)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8056974..8101997)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Leucine-CAG 1-3 Neighboring gene transfer RNA:Leucine-CAG 1-4 Neighboring gene transfer RNA:Leucine-CAG 1-5 Neighboring gene transfer RNA:Leucine-CAG 1-6 Neighboring gene transfer RNA:Leucine-CAG 1-7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43974 Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene Nuclear localized protein 1 Neighboring gene farinelli

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens. Gonzalez MA, et al. Biology (Basel), 2012 Dec 5. PMID 24832518, Free PMC Article
    2. Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Gu W, et al. Acta Crystallogr F Struct Biol Commun, 2021 Oct 1. PMID 34605441, Free PMC Article
    3. Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity. Sur M, et al. Cell Death Discov, 2018. PMID 30564462, Free PMC Article
    4. Axon Degeneration: Which Method to Choose? Coleman MP. Methods Mol Biol, 2020. PMID 32524468
    5. The circular RNA Edis regulates neurodevelopment and innate immunity. Xiong XP, et al. PLoS Genet, 2022 Oct. PMID 36301822, Free PMC Article

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early loss of endogenous NAD[+] following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
      Title: Early loss of endogenous NAD(+) following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition.
    2. Drosophila Ectoderm-expressed 4 modulates JAK/STAT pathway and protects flies against Drosophila C virus infection.
      Title: Drosophila Ectoderm-expressed 4 modulates JAK/STAT pathway and protects flies against Drosophila C virus infection.
    3. Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia.
      Title: Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia.
    4. In Ect4 knockdown flies Drosophila C virus-induced mortality occurred more quickly and virus accumulation was increased.
      Title: Drosophila miR-956 suppression modulates Ectoderm-expressed 4 and inhibits viral replication.
    5. findings show that loss of dSarm (sterile alpha/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously suppresses Wallerian degeneration for weeks after axotomy; results provide direct evidence that axons actively promote their own destruction after injury
      Title: dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables STAT family protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to axon injury IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterile alpha and armadillo motif
    Names
    CG43119-PD
    CG43119-PE
    CG43119-PF
    CG43119-PG
    CG43119-PH
    CG43119-PI
    CG43119-PJ
    CG43119-PK
    CG43119-PL
    CG43119-PM
    Ect4
    Ect4-derived immune suppressor
    Ectoderm-expressed 4
    SARM1
    Sarm-PD
    Sarm-PE
    Sarm-PF
    Sarm-PG
    Sarm-PH
    Sarm-PI
    Sarm-PJ
    Sarm-PK
    Sarm-PL
    Sarm-PM
    drosophila sterile alpha and armadillo motif
    sterile alpha, ARM, and TIR domain protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8063874..8108897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259733.1 → NP_001246662.1  sterile alpha and armadillo motif, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE45
      Conserved Domains (4) summary
      cd09501
      Location:1031 → 1099
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1100 → 1169
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:1031 → 1096
      SAM; Sterile alpha motif
      pfam13676
      Location:1185 → 1285
      TIR_2; TIR domain

    2. NM_001274627.1 → NP_001261556.1  sterile alpha and armadillo motif, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHR5
      Conserved Domains (4) summary
      cd09501
      Location:1031 → 1099
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1100 → 1169
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:1031 → 1096
      SAM; Sterile alpha motif
      pfam13676
      Location:1185 → 1285
      TIR_2; TIR domain

    3. NM_001104071.2 → NP_001097541.1  sterile alpha and armadillo motif, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN1
      Conserved Domains (4) summary
      cd09501
      Location:938 → 1006
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1007 → 1076
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:938 → 1003
      SAM; Sterile alpha motif
      pfam13676
      Location:1092 → 1192
      TIR_2; TIR domain

    4. NM_001104074.3 → NP_001097544.1  sterile alpha and armadillo motif, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN2
      Conserved Domains (4) summary
      cd09501
      Location:863 → 931
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:932 → 1001
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:863 → 928
      SAM; Sterile alpha motif
      pfam13676
      Location:1017 → 1117
      TIR_2; TIR domain

    5. NM_001104075.2 → NP_001097545.1  sterile alpha and armadillo motif, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN3
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain

    6. NM_001043129.3 → NP_001036594.1  sterile alpha and armadillo motif, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8H1, Q6IDD9, Q7KUA2, Q8SY48, Q9VSD2
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain

    7. NM_001259734.1 → NP_001246663.1  sterile alpha and armadillo motif, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFP2
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain

    8. NM_001382096.1 → NP_001369041.1  sterile alpha and armadillo motif, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7S1
      Conserved Domains (3) summary
      cd09501
      Location:505 → 573
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:574 → 643
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:658 → 795
      TIR; Toll - interleukin 1 - resistance

    9. NM_168254.2 → NP_729327.1  sterile alpha and armadillo motif, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6IDD9
      Related
      FBpp0293531
      Conserved Domains (4) summary
      cd09501
      Location:661 → 729
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:730 → 799
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:661 → 726
      SAM; Sterile alpha motif
      pfam13676
      Location:815 → 915
      TIR_2; TIR domain

    10. NM_001426711.1 → NP_001413639.1  sterile alpha and armadillo motif, isoform M [Drosophila melanogaster]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6M3Q7S1 A0A6M3Q7S1
    A8JNN1 A8JNN1
    A8JNN2 A8JNN2
    A8JNN3 A8JNN3
    M9NE45 M9NE45
    M9NFP2 M9NFP2
    M9PHR5 M9PHR5
    Q6IDD9.1 Q6IDD9

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