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    PGRP-LF Peptidoglycan recognition protein LF [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGRP-LFprovided by FlyBase
    Official Full Name
    Peptidoglycan recognition protein LFprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035977
    Locus tag
    Dmel_CG4437
    See related
    AllianceGenome:FB:FBgn0035977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.581; CG4437; Dmel\CG4437; PGRP; pgrp-lf; PGRP-like; PGRPLF
    Summary
    Enables signaling receptor binding activity. Involved in several processes, including antibacterial humoral response; determination of adult lifespan; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in plasma membrane. Is expressed in embryonic/larval fat body; embryonic/larval proventriculus; embryonic/larval salivary gland; epithelial tube; and imaginal disc. Orthologous to several human genes including PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGRP-LF in Genome Data Viewer
    Location:
    67B1-67B1; 3-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9349609..9351489)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9342709..9344589)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peptidoglycan recognition protein LA Neighboring gene Peptidoglycan recognition protein LC Neighboring gene UDP-glucose pyrophosphorylase Neighboring gene uncharacterized protein Neighboring gene small VCP interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. Basbous N, et al. EMBO Rep, 2011 Apr. PMID 21372849, Free PMC Article
    2. Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster. Seroude L, et al. Aging Cell, 2002 Oct. PMID 12882353
    3. Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE. Neyen C, et al. J Immunol, 2012 Aug 15. PMID 22772451
    4. Bacteria sensing mechanisms in Drosophila gut: Local and systemic consequences. Capo F, et al. Dev Comp Immunol, 2016 Nov. PMID 26778296
    5. Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan. Werner T, et al. J Biol Chem, 2003 Jul 18. PMID 12777387

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Negative regulation of NF-kappaB/IMD pathway by PGRP-LF is crucial to ensure proper induction of apoptosis and consequently normal fly development.
      Title: Inhibition of a NF-κB/Diap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development.
    2. Data show that the Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
      Title: The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.
    3. By genetically interacting with PGRP-LC, PGRP-LF prevents constitutive activation of both the JNK and the immune deficiency pathways in the absence of infection.
      Title: The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation.
    4. membrane bound and has its two PGRP domains, z and w, localized outside the cell
      Title: Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables N-acetylmuramoyl-L-alanine amidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in peptidoglycan catabolic process IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan recognition protein LF
    Names
    CG4437-PA
    PGRP-LF-PA
    PRGP-like
    Peptidoglycan-recognition protein-LF
    peptidoglycan recognition protein
    peptidoglycan recognition protein-LF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9349609..9351489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140042.3 → NP_648299.3  peptidoglycan recognition protein LF [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648299.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SXQ7, Q9VSW0
      Related
      FBpp0076167
      Conserved Domains (2) summary
      smart00701
      Location:57 → 199
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
      cl02712
      Location:236 → 363
      PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXQ7.1 Q8SXQ7

    Gene LinkOut

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