Pmm2 Phosphomannomutase type 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pmm2provided by FlyBase
Official Full Name: Phosphomannomutase type 2provided by FlyBase
Primary source: FLYBASE:FBgn0036300
Locus tag: Dmel_CG10688
See related: AllianceGenome:FB:FBgn0036300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 33589256; CG10688; Dmel\CG10688; pmm2
Summary: Predicted to enable phosphomannomutase activity. Involved in cellular response to hypoxia and protein N-linked glycosylation. Predicted to be active in cytosol. Is expressed in adult head. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation Ia. Orthologous to human PMM1 (phosphomannomutase 1) and PMM2 (phosphomannomutase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 69C6-69C6; 3-38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12534590..12535513)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12527690..12528613)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR-generated pmm2-null Drosophila mutants display severely disrupted glycosylation and early lethality.
Title: Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm1613 (e-PCR)
- UniSTS:57085

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphomannomutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphomannomutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate	ISS Inferred from Sequence or Structural Similarity more info
involved_in GDP-mannose biosynthetic process from mannose	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphomannomutase type 2

Names: CG10688-PA; Pmm2-PA; phosphomannomutase-2

NP_648589.1

EC 5.4.2.8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12534590..12535513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140332.2 → NP_648589.1 phosphomannomutase type 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648589.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VTZ6

Related

FBpp0075693

Conserved Domains (1) summary

cd02585
Location:12 → 251

HAD_PMM; phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM