dlp dally-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dlpprovided by FlyBase
Official Full Name: dally-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0041604
Locus tag: Dmel_CG32146
See related: AllianceGenome:FB:FBgn0041604
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17703; CG32146; CG5031; CT16138; D-gpcB; Dally-like; Dlp; DLP; dly; Dly; Dmel\CG32146
Summary: Enables Wnt-protein binding activity and hedgehog family protein binding activity. Involved in several processes, including epithelial cell migration, open tracheal system; positive regulation of signal transduction; and regionalization. Located in several cellular components, including cytoneme; external side of plasma membrane; and neuromuscular junction. Is expressed in several structures, including anlage in statu nascendi; follicle cell; head epidermis primordium; mesoderm; and tract. Human ortholog(s) of this gene implicated in Keipert syndrome and omodysplasia 1. Orthologous to several human genes including GPC1 (glypican 1); GPC4 (glypican 4); and GPC6 (glypican 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70E5-70E7; 3-42 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14632601..14671609)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14625701..14664709)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Title: TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway.
Title: The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway.
Dally and Dally-like, are necessary for injury-induced thermal allodynia
Title: Glypicans Dally and Dally-like control injury-induced allodynia in Drosophila.
dlp is a hypercompetitive mutation: dlp mutant follicle stem cell progenitors often eventually occupy the entire epithelial sheet.
Title: Drosophila Glypicans Regulate Follicle Stem Cell Maintenance and Niche Competition.
ECM over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).
Title: Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes.
The authors show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient.
Title: Pentagone internalises glypicans to fine-tune multiple signalling pathways.
DLP and ASF1 are part of a predeposition complex, which is recruited by XNP and is necessary to prevent DNA exposure in the nucleus.
Title: The Drosophila DAXX-Like Protein (DLP) Cooperates with ASF1 for H3.3 Deposition and Heterochromatin Formation.
data suggest that Dally and Dlp are essential regulators for Upd distribution and JAK/STAT signaling activity in eye development
Title: Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
findings demonstrate that the glypican dlp regulates formation of the follicular gradient of the Upd morphogen, Upd
Title: Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Data show that Dispatched could be involved in the regulation of vesicular trafficking necessary for basolateral release of Hh, Dlp, and Ihog.
Title: Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables hedgehog family protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in cytoneme	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in perivitelline space	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dally-like

Names: CG32146-PA; CG32146-PC; D-glypican B; Dally-like; Dally-like protein; dallylike; dlp-PA; dlp-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14632601..14671609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079347.3 → NP_524071.2 dally-like, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q960K1, Q9GPL5, Q9VUG1

Related

FBpp0075431

Conserved Domains (1) summary

pfam01153
Location:79 → 613

Glypican; Glypican
NM_206353.2 → NP_996075.2 dally-like, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KUL1, Q9GPL5

Conserved Domains (1) summary

pfam01153
Location:79 → 613

Glypican; Glypican