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    Pi4KIIalpha Phosphatidylinositol 4-kinase II alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pi4KIIalphaprovided by FlyBase
    Official Full Name
    Phosphatidylinositol 4-kinase II alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037339
    Locus tag
    Dmel_CG2929
    See related
    AllianceGenome:FB:FBgn0037339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2929; Dmel\CG2929; Pi4KII; PI4KII; Pi4KIIa; PI4KIIa; PI4KIIA; PI4KIIalpha; PI4KIIbeta
    Summary
    Enables 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including Golgi organization; phosphatidylinositol phosphate biosynthetic process; and vesicle organization. Located in late endosome membrane and trans-Golgi network. Is expressed in embryonic/larval salivary gland and organism. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha) and PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pi4KIIalpha in Genome Data Viewer
    Location:
    83B1-83B2; 3-47.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5557663..5563652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1383385..1389374, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene meiosis I arrest Neighboring gene Protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene Snm1 Neighboring gene ncRNA Neighboring gene antisense RNA:CR46136 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II. Barylko B, et al. J Biol Chem, 2002 Nov 15. PMID 12215430
    2. Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling. Cantarutti KC, et al. J Neurogenet, 2018 Sep. PMID 30175671
    3. Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II. Koe CT, et al. Elife, 2018 Feb 27. PMID 29482721, Free PMC Article
    4. The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye. Del Bel LM, et al. Development, 2018 May 31. PMID 29752385, Free PMC Article
    5. Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila. Csizmadia T, et al. Traffic, 2022 Dec. PMID 36353974, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PI4KII is required for synaptic vesicles (SVs) endocytosis but dispensable for SV exocytosis
      Title: Type II phosphatidylinositol 4-kinase regulates nerve terminal growth and synaptic vesicle recycling.
    2. In PI4KII mutants, mucin-containing glue granules failed to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late endosomes.
      Title: Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila.
    3. expressed and characterized Drosophila PI4KII and its catalytic domain
      Title: Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-kinase II alpha
    Names
    CG2929-PA
    CG2929-PB
    CG2929-PC
    CG2929-PE
    CG2929-PF
    Pi4KIIalpha-PA
    Pi4KIIalpha-PB
    Pi4KIIalpha-PC
    Pi4KIIalpha-PE
    Pi4KIIalpha-PF
    NP_001368956.1
    NP_001368992.1
    NP_730944.2
    NP_730945.1
    NP_996154.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5557663..5563652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206432.3 → NP_996154.1  phosphatidylinositol 4-kinase II alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZH2, Q8STF7, Q9VND3
      Conserved Domains (1) summary
      cl21453
      Location:293 → 474
      PKc_like; Protein Kinases, catalytic domain

    2. NM_169063.4 → NP_730944.2  phosphatidylinositol 4-kinase II alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730944.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZH2, Q8STF7, Q9VND3
      Related
      FBpp0089178
      Conserved Domains (1) summary
      cl21453
      Location:293 → 474
      PKc_like; Protein Kinases, catalytic domain

    3. NM_169064.2 → NP_730945.1  phosphatidylinositol 4-kinase II alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0B7
      Related
      FBpp0078404
      Conserved Domains (1) summary
      cl21453
      Location:146 → 327
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001382052.1 → NP_001368956.1  phosphatidylinositol 4-kinase II alpha, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6F7SG83
      Conserved Domains (1) summary
      cl21453
      Location:62 → 244
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001382053.1 → NP_001368992.1  phosphatidylinositol 4-kinase II alpha, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EES5, D6W4K4
      Conserved Domains (1) summary
      cl21453
      Location:39 → 221
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6F7SG83 A0A6F7SG83
    A0A6H2EES5 A0A6H2EES5
    Q8I0B7 Q8I0B7
    Q8STF7 Q8STF7
    Q9VND3 Q9VND3

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