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    Srp14 Signal recognition particle 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42436, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srp14provided by FlyBase
    Official Full Name
    Signal recognition particle 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0038808
    Locus tag
    Dmel_CG5417
    See related
    AllianceGenome:FB:FBgn0038808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE48595; CG5417; Dmel\CG5417; SRP14
    Summary
    Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in organism. Orthologous to human SRP14 (signal recognition particle 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Srp14 in Genome Data Viewer
    Location:
    92F2-92F2; 3-69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20580115..20580764)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16405837..16406486)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Elongin B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Septin 2 Neighboring gene antisense RNA:CR46044

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
    2. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    3. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article
    4. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams EW, et al. Development, 2005 Jun. PMID 15901661
    5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 14
    Names
    CG5417-PB
    Srp14-PB
    signal recognition particle protein 14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20580115..20580764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142639.4 → NP_650896.2  signal recognition particle 14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650896.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAA2, Q9VDL0
      Conserved Domains (1) summary
      pfam02290
      Location:4 → 94
      SRP14; Signal recognition particle 14kD protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGQ4 Q8IGQ4
    Q9VDL0 Q9VDL0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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