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    Smyd5 SET and MYND domain containing, class 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smyd5provided by FlyBase
    Official Full Name
    SET and MYND domain containing, class 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038869
    Locus tag
    Dmel_CG3353
    See related
    AllianceGenome:FB:FBgn0038869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3353; Dmel\CG3353
    Summary
    Predicted to enable histone H4K20 methyltransferase activity. Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be located in chromatin. Is expressed in anterior midgut primordium; embryonic/larval midgut; larval muscle system; organism; and posterior midgut primordium. Orthologous to human SMYD5 (SMYD family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smyd5 in Genome Data Viewer
    Location:
    93C6-93C6; 3-71 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21217268..21218791, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17042990..17044513, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene DDRGK domain containing 1 Neighboring gene pseudo Neighboring gene O-GlcNAcase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44265 Neighboring gene Negative elongation factor A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Stender JD, et al. Mol Cell, 2012 Oct 12. PMID 22921934, Free PMC Article
    2. Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster. Takahashi A, et al. Genetics, 2007 Oct. PMID 17660557, Free PMC Article
    3. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    4. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï M, et al. J Neurobiol, 2003 Dec. PMID 14608664
    5. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    SET and MYND domain containing, class 5
    Names
    CG3353-PA
    Smyd5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21217268..21218791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142698.2 → NP_650955.1  SET and MYND domain containing, class 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650955.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDD0
      Related
      FBpp0083507
      Conserved Domains (2) summary
      pfam00856
      Location:296 → 333
      SET; SET domain
      pfam01753
      Location:87 → 118
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDD0 Q9VDD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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