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    Nepl13 Neprilysin-like 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42699, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nepl13provided by FlyBase
    Official Full Name
    Neprilysin-like 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0039022
    Locus tag
    Dmel_CG4725
    See related
    AllianceGenome:FB:FBgn0039022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4725; Dmel\CG4725
    Summary
    Predicted to be involved in proteolysis. Located in extracellular region. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nepl13 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22758810..22761076, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18584532..18586798, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1c Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 14 Neighboring gene Neprilysin-like 15

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in extracellular region PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Neprilysin-like 13
    Names
    CG4725-PA
    Nepl13-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22758810..22761076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142839.4 → NP_651096.1  Neprilysin-like 13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVL8, Q9VCU3
      Related
      FBpp0083712
      Conserved Domains (2) summary
      cd08662
      Location:68 → 738
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:63 → 732
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
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