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    CG31075 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31075provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051075
    Locus tag
    Dmel_CG31075
    See related
    AllianceGenome:FB:FBgn0051075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    150697_at; CG6309; CT19744; Dmel\CG31075; GH20910p
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in pyruvate metabolic process. Predicted to be located in mitochondrion. Is expressed in adult brain; adult head; adult pars intercerebralis; and organism. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1) and ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31075 in Genome Data Viewer
    Location:
    97D12-97D12; 3-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26985624..26988517, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22811346..22814239, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 97a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleC

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sex-dependent and sex-independent regulatory systems of size variation in natural populations. Okada H, et al. Mol Syst Biol, 2019 Nov. PMID 31777173, Free PMC Article
    2. The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells. Zipper L, et al. Metabolites, 2022 Mar 31. PMID 35448502, Free PMC Article
    3. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. Shim MS, et al. J Biol Chem, 2009 Nov 20. PMID 19755423, Free PMC Article
    4. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
    5. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31075-PA
    CG31075-PB
    NP_001247324.1
    NP_733183.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26985624..26988517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170304.2 → NP_733183.1  uncharacterized protein Dmel_CG31075, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNE9, Q9VB96
      Related
      FBpp0084452
      Conserved Domains (1) summary
      cl11961
      Location:5 → 483
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    2. NM_001260395.2 → NP_001247324.1  uncharacterized protein Dmel_CG31075, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6I6, A9UNE9
      Conserved Domains (1) summary
      cl11961
      Location:33 → 506
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6I6 A0A0B4K6I6
    Q9VB96 Q9VB96

    Gene LinkOut

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