dj-1beta dj-1beta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dj-1betaprovided by FlyBase
Official Full Name: dj-1betaprovided by FlyBase
Primary source: FLYBASE:FBgn0039802
Locus tag: Dmel_CG1349
See related: AllianceGenome:FB:FBgn0039802
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1349; dDJ-1beta; DJ-1; DJ-1 beta; dj-1b; DJ-1b; DJ-1B; Dj-1beta; DJ-1beta; DJ1-1beta; dj1-beta; Dmel\CG1349
Summary: Predicted to enable peroxiredoxin activity and protein deglycase activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of mitochondrial ATP synthesis coupled electron transport. Located in mitochondrion. Is expressed in organism and spermatozoon. Used to study Parkinson's disease; Parkinson's disease 7; and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100A5-100A5; 3-101 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30807117..30807978)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26632839..26633700)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolic Alterations in a Drosophila Model of Parkinson's Disease Based on DJ-1 Deficiency.
Title: Metabolic Alterations in a Drosophila Model of Parkinson's Disease Based on DJ-1 Deficiency.
Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency.
Title: Enhanced activity of glycolytic enzymes in Drosophila and human cell models of Parkinson's disease based on DJ-1 deficiency.
Dj-1beta regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.
Title: dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.
the oxidation of conserved cysteine residue to its sulfinate form (Cys-SO(2)(-)) results in considerable thermal stabilization of both Drosophila DJ-1beta and human DJ-1
Title: Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1.
Flies deleted for DJ-1 manifest similar defects as pink1 and parkin mutants: male sterility, shortened lifespan, and reduced climbing ability.
Title: DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.
Loss-of-function DJ-1beta mutants demonstrated an extended survival of dopaminergic neurons and resistance to paraquat stress, but showed acute sensitivity to hydrogen peroxide treatment.
Title: Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.
DJ-1beta protein is biochemically responsive to oxidative stress, and mutant DJ-1 flies are selectively sensitive to environmental toxins associated with Parkinson's disease.
Title: Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
Data show that human DJ-1 rescues flies mutant for DJ-1b; a conserved cysteine in is critical for antioxidant function, and suggest that overoxidation of DJ-1 with age and exposure to oxidants can cause inactivation.
Title: Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables peroxiredoxin activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein deglycase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in methylglyoxal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein deglycation, methylglyoxal removal	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in protein deglycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial ATP synthesis coupled electron transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dj-1beta

Names: CG1349-PB; DJ-1B; dj-1beta-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30807117..30807978

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143568.3 → NP_651825.4 dj-1beta [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KXK5, Q95SP6, Q9VA37

Conserved Domains (1) summary

TIGR01383
Location:4 → 181

not_thiJ; DJ-1 family protein