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    stops slow termination of phototransduction [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stopsprovided by FlyBase
    Official Full Name
    slow termination of phototransductionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086704
    Locus tag
    Dmel_CG31006
    See related
    AllianceGenome:FB:FBgn0086704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15557; CG15558; CG15559; CG31006; Dmel\CG31006; su(rdgB)69
    Summary
    Involved in phospholipase C-activating opsin-mediated signaling pathway and sensory perception of sound. Orthologous to human ASB17 (ankyrin repeat and SOCS box containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stops in Genome Data Viewer
    Location:
    100B4-100B5; 3-102 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31158156..31169106, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26983878..26994828, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46207 Neighboring gene long non-coding RNA:CR43458 Neighboring gene Guanylyl cyclase beta-subunit at 100B Neighboring gene mesh Neighboring gene bottleneck Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of Drosophila retinal degeneration B suppressors. Paetkau DW, et al. Genetics, 1999 Feb. PMID 9927463, Free PMC Article
    2. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Wang T, et al. Neuron, 2008 Jan 10. PMID 18184564, Free PMC Article
    3. Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Diao F, et al. Cell Rep, 2015 Mar 3. PMID 25732830, Free PMC Article
    4. Vitamin A deficiency affects gene expression in the Drosophila melanogaster head. Dewett D, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849795, Free PMC Article
    5. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STOPS is the first protein identified that specifically regulates PLCbeta protein concentration.
      Title: The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating opsin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slow termination of phototransduction
    Names
    CG31006-PA
    CG31006-PB
    CG31006-PC
    stops-PA
    stops-PB
    stops-PC
    suppressor (rdgB) 69

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31158156..31169106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170538.3 → NP_733417.1  slow termination of phototransduction, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRT4
      Related
      FBpp0085142
      Conserved Domains (1) summary
      pfam07525
      Location:294 → 332
      SOCS_box; SOCS box

    2. NM_001170309.2 → NP_001163780.1  slow termination of phototransduction, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRT4
      Conserved Domains (1) summary
      pfam07525
      Location:294 → 332
      SOCS_box; SOCS box

    3. NM_170537.2 → NP_733416.2  slow termination of phototransduction, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733416.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961U2, Q9VA06
      Related
      FBpp0085143
      Conserved Domains (1) summary
      pfam07525
      Location:370 → 408
      SOCS_box; SOCS box
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KRT4 Q7KRT4
    Q9VA06 Q9VA06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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