Gat GABA transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gatprovided by FlyBase
Official Full Name: GABA transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0039915
Locus tag: Dmel_CG1732
See related: AllianceGenome:FB:FBgn0039915
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0149848.11; CG1732; CG1732a; dGAT; Dmel\CG1732; DmGAT; gat; GAT
Summary: Predicted to enable gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in cellular response to mechanical stimulus. Located in glial cell projection and plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; larval nervous system; larval ventral nerve cord; and optic lobe neuroepithelial cell. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (629691..635350)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (650317..655976)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid transport	ISM Inferred from Sequence Model more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain