U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG11155 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43822, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG11155provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039927
    Locus tag
    Dmel_CG11155
    See related
    AllianceGenome:FB:FBgn0039927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT30863; DmelCG11155; Dmel\CG11155
    Summary
    Predicted to enable kainate selective glutamate receptor activity. Involved in glutamatergic synaptic transmission and positive regulation of synaptic plasticity. Is active in postsynaptic membrane. Is expressed in adult head and transmedullary neuron Tm5c. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive intellectual developmental disorder 6; childhood absence epilepsy; and chronic obstructive pulmonary disease. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1) and GRIK2 (glutamate ionotropic receptor kainate type subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG11155 in Genome Data Viewer
    Location:
    102F8-102F8; 4-0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1126602..1137919)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1147228..1158545)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene shaven Neighboring gene Calsyntenin Neighboring gene ADP ribosylation factor 4 Neighboring gene uncharacterized protein Neighboring gene Kinesin family member 3C Neighboring gene pleiohomeotic

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development. Nguyen TH, et al. Dev Cell, 2024 May 6. PMID 38569548,
    2. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Sackton TB, et al. Genome Biol Evol, 2009 Nov 18. PMID 20333214, Free PMC Article
    3. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone DE, et al. J Neurosci, 2005 Mar 23. PMID 15788777, Free PMC Article
    4. Novel Functional Properties of Drosophila CNS Glutamate Receptors. Li Y, et al. Neuron, 2016 Dec 7. PMID 27889096, Free PMC Article
    5. A hard-wired glutamatergic circuit pools and relays UV signals to mediate spectral preference in Drosophila. Karuppudurai T, et al. Neuron, 2014 Feb 5. PMID 24507194, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 1127678-1128075 mobile_element_type = transposon:INE-1{}3938
    • Loc: 1130643-1130856 mobile_element_type = transposon:INE-1{}3940
    • Loc: 1136023-1136077 mobile_element_type = transposon:INE-1{}3945

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kainate selective glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG11155-PA
    CG11155-PB
    CG11155-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1126602..1137919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166825.3 → NP_726649.3  uncharacterized protein Dmel_CG11155, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726649.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U168, Q8IM94, Q9V4A0
      Conserved Domains (4) summary
      cd06382
      Location:44 → 410
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:424 → 793
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:555 → 829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:61 → 393
      ANF_receptor; Receptor family ligand binding region

    2. NM_143684.3 → NP_651941.2  uncharacterized protein Dmel_CG11155, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651941.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U168, Q8IM94, Q9V4A0
      Conserved Domains (4) summary
      cd06382
      Location:44 → 410
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      cd13714
      Location:424 → 793
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      pfam00060
      Location:555 → 829
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:61 → 393
      ANF_receptor; Receptor family ligand binding region

    3. NM_166824.3 → NP_726648.2  uncharacterized protein Dmel_CG11155, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726648.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IM95
      Conserved Domains (3) summary
      cd06382
      Location:44 → 410
      PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors
      pfam01094
      Location:61 → 393
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:424 → 855
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U168 Q5U168
    Q8IM95 Q8IM95
    Q8MSY7 Q8MSY7
    Q9V4A0 Q9V4A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous