Letm1 Leucine zipper and EF-hand containing transmembrane protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Letm1provided by FlyBase
Official Full Name: Leucine zipper and EF-hand containing transmembrane protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0284252
Locus tag: Dmel_CG4589
See related: AllianceGenome:FB:FBgn0284252
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-60Da; anon60Da; B4D; CG4589; dLetm1; Dmel\CG4589; DmLETM1; l(2)k10502; letm1
Summary: Enables calcium:sodium antiporter activity and potassium:proton antiporter activity. Involved in several processes, including cellular response to hypoxia; monoatomic cation transmembrane transport; and neurotransmitter secretion. Located in mitochondrial membrane. Is expressed in several structures, including adult head; adult heart; central brain primordium; embryonic/larval midgut; and head epidermis primordium. Used to study Wolf-Hirschhorn syndrome. Orthologous to several human genes including LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60D3-60D3; 2-107 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24509508..24515320, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20397031..20402843, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate the function of DmLETM1 as a mitochondrial osmoregulator.
Title: A Drosophila mutant of LETM1, a candidate gene for seizures in Wolf-Hirschhorn syndrome.
CG4589, the Drosophila homolog of the human gene Letm1, was identified as a gene strongly affecting [Ca2+]mito and [H+]mito responses
Title: Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine zipper and EF-hand containing transmembrane protein 1

Names: CG4589-PA; CG4589-PB; CG4589-PC; LETM1 ortholog; Letm1-PA; Letm1-PB; Letm1-PC; lethal (2) k10502

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24509508..24515320 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138078.3 → NP_611922.1 leucine zipper and EF-hand containing transmembrane protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV1, P91927, Q0E8W7, Q9W160

Related

FBpp0072255

Conserved Domains (2) summary

pfam07766
Location:184 → 438

LETM1; LETM1-like protein

cl08302
Location:774 → 823

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_166674.2 → NP_726453.1 leucine zipper and EF-hand containing transmembrane protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV1, P91927, Q0E8W7, Q9W160

Related

FBpp0072254

Conserved Domains (2) summary

pfam07766
Location:184 → 438

LETM1; LETM1-like protein

cl08302
Location:774 → 823

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_166675.2 → NP_726454.1 leucine zipper and EF-hand containing transmembrane protein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZV1, P91927, Q0E8W7, Q9W160

Related

FBpp0072256

Conserved Domains (2) summary

pfam07766
Location:184 → 438

LETM1; LETM1-like protein

cl08302
Location:774 → 823

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...