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    sno strawberry notch [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32273, updated on 17-Dec-2024

    Summary

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    Official Symbol
    snoprovided by FlyBase
    Official Full Name
    strawberry notchprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265630
    Locus tag
    Dmel_CG44436
    See related
    AllianceGenome:FB:FBgn0265630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1903; CG44436; Dmel\CG44436; g-l; l(1)11Ea; Sno
    Old locus tag
    Dmel_CG1903
    Summary
    Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; and wing disc development. Located in nucleus. Is expressed in several structures, including dorsal mesothoracic pleura primordium; epithelium; imaginal disc; mesectoderm; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including SBNO1 (strawberry notch homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sno in Genome Data Viewer
    Location:
    11E3-11E3; 1-42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13195499..13211674, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13089532..13105707, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q5 Neighboring gene uncharacterized protein Neighboring gene Proteasome regulator gamma Neighboring gene multiple edematous wings Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila proteasome regulator REGgamma: transcriptional activation by DNA replication-related factor DREF and evidence for a role in cell cycle progression. Masson P, et al. J Mol Biol, 2003 Apr 11. PMID 12662925
    2. Scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila. Nagel AC, et al. Mech Dev, 2001 Dec. PMID 11731237
    3. ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue. Carrasco J, et al. Mol Cell, 2020 Oct 1. PMID 33007255
    4. An RNA polymerase II mutation in Drosophila melanogaster that mimics ultrabithorax. Mortin MA, et al. Chromosoma, 1981. PMID 6785043
    5. MSL2 combines sensor and effector functions in homeostatic control of the Drosophila dosage compensation machinery. Villa R, et al. Mol Cell, 2012 Nov 30. PMID 23084834

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that dSno functions as a tissue-specific component of the Wg signaling pathway with modest antagonistic activity under normal conditions but capable of blocking significant levels of extraneous Wg, a role that may be conserved in vertebrates.
      Title: The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila.
    2. An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
      Title: An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
    3. sno is an inhibitor of dpp.
      Title: The role of Dpp and its inhibitors during eggshell patterning in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    strawberry notch
    Names
    CG44436-PA
    CG44436-PB
    glossy-like
    sno-PA
    sno-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13195499..13211674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078589.4 → NP_511144.2  strawberry notch, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511144.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUV0
      Related
      FBpp0309424
      Conserved Domains (2) summary
      pfam13871
      Location:1022 → 1299
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:342 → 645
      AAA_34; P-loop containing NTP hydrolase pore-1

    2. NM_001103497.2 → NP_001096967.1  strawberry notch, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JUU9, A8JUV0, O01940, Q8MZI4, Q95S83, Q9VYF7
      Conserved Domains (2) summary
      pfam13871
      Location:1128 → 1405
      Helicase_C_4; C-terminal domain on Strawberry notch homologue
      pfam13872
      Location:448 → 751
      AAA_34; P-loop containing NTP hydrolase pore-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUV0.2 A8JUV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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