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    Mtr4 Mtr4 helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtr4provided by FlyBase
    Official Full Name
    Mtr4 helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001986
    Locus tag
    Dmel_CG4152
    See related
    AllianceGenome:FB:FBgn0001986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07290; BG:DS09217.2; br44; cg4152; CG4152; Dmel\CG4152; dMtr4; l(2)35Df; L(2)35Df; l(2)br44; l(2)k14422; l(2)k14423; l.2.35Df; lethal(2)35Df
    Summary
    Predicted to enable RNA helicase activity. Involved in defense response to virus. Part of catalytic step 2 spliceosome. Is expressed in adult head and organism. Orthologous to human MTREX (Mtr4 exosome RNA helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtr4 in Genome Data Viewer
    Location:
    35D4-35D4; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15752263..15755900)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15752263..15755900)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B17 subunit Neighboring gene small nuclear RNA U5 at 35D Neighboring gene Gliotactin Neighboring gene uncharacterized protein Neighboring gene weckle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of speciation by means of introgression into Drosophila melanogaster. Sawamura K, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10706624, Free PMC Article
    2. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
    3. Effects of codon usage on gene expression are promoter context dependent. Yang Q, et al. Nucleic Acids Res, 2021 Jan 25. PMID 33410890, Free PMC Article
    4. A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation. Molleston JM, et al. Genes Dev, 2016 Jul 15. PMID 27474443, Free PMC Article
    5. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Furukawa T, et al. Cell, 1992 Jun 26. PMID 1617729

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Mtr4 helicase
    Names
    CG4152-PA
    Mtr4-PA
    lethal (2) 35Df
    NP_524929.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15752263..15755900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080190.3 → NP_524929.1  Mtr4 helicase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y134
      Related
      FBpp0080319
      Conserved Domains (5) summary
      COG4581
      Location:91 → 1055
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      cd00079
      Location:390 → 554
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:154 → 299
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:881 → 1048
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:600 → 853
      rRNA_proc-arch; rRNA-processing arch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y134 Q9Y134

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