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    S-Lap8 Sperm-Leucylaminopeptidase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S-Lap8provided by FlyBase
    Official Full Name
    Sperm-Leucylaminopeptidase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0034132
    Locus tag
    Dmel_CG4439
    See related
    AllianceGenome:FB:FBgn0034132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.41; CG4439; Dmel\CG4439; FBgn0034132; S-Lap 8; S-LAP 8
    Summary
    Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See S-Lap8 in Genome Data Viewer
    Location:
    53C6-53C6; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16491100..16493233)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12378605..12380738)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene knotted onions Neighboring gene Semaphorin 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
    2. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
    3. Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Dorus S, et al. Nat Genet, 2006 Dec. PMID 17099714
    4. Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. Mikhaylova LM, et al. BMC Biol, 2011 May 4. PMID 21542906, Free PMC Article
    5. Functional Diversity and Evolution of the Drosophila Sperm Proteome. Garlovsky MD, et al. Mol Cell Proteomics, 2022 Oct. PMID 35985624, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables metalloaminopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in major mitochondrial derivative ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Sperm-Leucylaminopeptidase 8
    Names
    CG4439-PA
    S-Lap8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16491100..16493233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137288.3 → NP_611132.1  Sperm-Leucylaminopeptidase 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611132.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5K9
      Related
      FBpp0086235
      Conserved Domains (2) summary
      COG0260
      Location:66 → 532
      PepB; Leucyl aminopeptidase [Amino acid transport and metabolism]
      cd00433
      Location:51 → 528
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5K9 Q7K5K9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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