glob1 globin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: glob1provided by FlyBase
Official Full Name: globin 1provided by FlyBase
Primary source: FLYBASE:FBgn0027657
Locus tag: Dmel_CG9734
See related: AllianceGenome:FB:FBgn0027657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9734; DmeGb1; dmeglob1; DmeGlob1; Dmel\CG9734; DmHb; DmHb1; DroHb; Glob1; globin1; Hb
Summary: Enables iron ion binding activity and oxygen binding activity. Predicted to be involved in oxygen transport and response to hypoxia. Located in plasma membrane. Is expressed in several structures, including epithelium; fat body; gonad; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; congenital hemolytic anemia (multiple); polycythemia (multiple); sickle cell disease (multiple); and thalassemia (multiple). Orthologous to several human genes including CYGB (cytoglobin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89A8-89A8; 3-58 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15896926..15904643, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11722648..11730243, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
Title: Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
Title: Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
Glob1 expression is essential for neurogenesis in Drosophila. Downregulation of glob1 causes mispositioning of neuronal precursor cells and neuromuscular disabilities.
Title: Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila.
Authors have performed a comprehensive investigation on the cellular expression profile and functional relevance of glob1 in Drosophila development.
Title: Drosophila glob1 expresses dynamically and is required for development and oxidative stress response.
Several pH-dependent low-spin ferric haem forms are identified in a frozen solution of the ferric (1)(2)(1)Cys-->Ser mutant of Drosophila melanogaster haemoglobin (DmHb1*) using electron paramagnetic resonance (EPR) techniques.
Title: Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin.
expression levels of dmeglob1 are decreased under both short- and long-term hypoxia
Title: Oxygen-induced changes in hemoglobin expression in Drosophila.
Characterization of Drosophila hemoglobin
Title: Characterization of Drosophila hemoglobin. Evidence for hemoglobin-mediated respiration in insects.
crystal structure of recombinant D. melanogaster hemoglobin at 1.20 A resolution displays a hexacoordinated heme, whose axial ligands are the proximal and distal His residues and three protein matrix cavities
Title: Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.
molecular characterization of human and Drosophila cytoglobulins and neuroglobulins
Title: Hyperthermal stability of neuroglobin and cytoglobin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISM Inferred from Sequence Model more info	PubMed
enables iron ion binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen binding	ISM Inferred from Sequence Model more info	PubMed
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxygen transport	IC Inferred by Curator more info	PubMed
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: globin 1

Names: CG9734-PA; CG9734-PB; CG9734-PC; CG9734-PD; CG9734-PE; CG9734-PF; glob1-PA; glob1-PB; glob1-PC; glob1-PD; glob1-PE; glob1-PF; globin; haemoglobin; hemoglobin; hemoglobin gene 1

NP_001163625.1

EC 1.11.1.-

NP_001287343.1

EC 1.11.1.-

NP_524369.1

EC 1.11.1.-

NP_732081.1

EC 1.11.1.-

NP_732082.1

EC 1.11.1.-

NP_732083.1

EC 1.11.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15896926..15904643 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300414.2 → NP_001287343.1 globin 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287343.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1K3, Q9VF15

Conserved Domains (1) summary

cd01040
Location:9 → 142

Mb_like; myoglobin_like; M family globin domain
NM_169679.3 → NP_732082.1 globin 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732082.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1K3, Q9VF15

Related

FBpp0082699

Conserved Domains (1) summary

cd01040
Location:9 → 142

Mb_like; myoglobin_like; M family globin domain
NM_169680.3 → NP_732083.1 globin 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732083.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1K3, Q9VF15

Related

FBpp0082702

Conserved Domains (1) summary

cd01040
Location:9 → 142

Mb_like; myoglobin_like; M family globin domain
NM_079645.4 → NP_524369.1 globin 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524369.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1K3, Q9VF15

Related

FBpp0082700

Conserved Domains (1) summary

cd01040
Location:9 → 142

Mb_like; myoglobin_like; M family globin domain
NM_169678.2 → NP_732081.1 globin 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732081.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U1K3, Q9VF15

Related

FBpp0082701

Conserved Domains (1) summary

cd01040
Location:9 → 142

Mb_like; myoglobin_like; M family globin domain
NM_001170154.3 → NP_001163625.1 globin 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163625.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T0T2

Conserved Domains (1) summary

cl21461
Location:9 → 59

Globin-like; Globin-like protein superfamily