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    Wdr81 WD repeat domain 81 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr81provided by FlyBase
    Official Full Name
    WD repeat domain 81provided by FlyBase
    Primary source
    FLYBASE:FBgn0032395
    Locus tag
    Dmel_CG6734
    See related
    AllianceGenome:FB:FBgn0032395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6734; CG6734; Dmel\CG6734; dWDR81
    Summary
    Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Involved in positive regulation of mitotic cell cycle phase transition. Predicted to be located in cytosol and early endosome membrane. Predicted to be active in early endosome and late endosome. Used to study microcephaly. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr81 in Genome Data Viewer
    Location:
    33B8-33B9; 2-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12014304..12020960, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12014304..12020960, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Rhodopsin 5 Neighboring gene long non-coding RNA:CR44588 Neighboring gene long non-coding RNA:CR44587 Neighboring gene Dietary and metabolic glutamate transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells. Cavallin M, et al. Brain, 2017 Oct 1. PMID 28969387
    2. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF. Jensen LT, et al. Cell Stress Chaperones, 2008 Summer. PMID 18759003, Free PMC Article
    3. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat domain 81
    Names
    CG6734-PA
    Wdr81-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12014304..12020960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135691.2 → NP_609535.1  WD repeat domain 81 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKD0
      Related
      FBpp0079896
      Conserved Domains (4) summary
      cd06071
      Location:345 → 588
      Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
      COG2319
      Location:1644 → 1877
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1662 → 1705
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:1651 → 1876
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKD0 Q9VKD0

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