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    Adk2 Adenosine kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adk2provided by FlyBase
    Official Full Name
    Adenosine kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036337
    Locus tag
    Dmel_CG11255
    See related
    AllianceGenome:FB:FBgn0036337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Adenok; AdenoK; AdoK; CG11255; DmAdk2; Dmel\CG11255
    Summary
    Predicted to enable adenosine kinase activity. Predicted to be involved in AMP biosynthetic process and purine nucleobase metabolic process. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain; adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and larval muscle cell. Human ortholog(s) of this gene implicated in hypermethioninemia due to adenosine kinase deficiency. Orthologous to human ADK (adenosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adk2 in Genome Data Viewer
    Location:
    69F5-69F5; 3-39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13019715..13022688, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13012815..13015788, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene antisense RNA:CR45445 Neighboring gene Isoprenylcysteine carboxyl methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
    2. Release of promoter-proximal paused Pol II in response to histone deacetylase inhibition. Vaid R, et al. Nucleic Acids Res, 2020 May 21. PMID 32297950, Free PMC Article
    3. Adenosine Receptor and Its Downstream Targets, Mod(mdg4) and Hsp70, Work as a Signaling Pathway Modulating Cytotoxic Damage in Drosophila. Lin YH, et al. Front Cell Dev Biol, 2021. PMID 33777958, Free PMC Article
    4. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077
    5. Epithelial cells release adenosine to promote local TNF production in response to polarity disruption. Poernbacher I, et al. Nat Commun, 2018 Nov 7. PMID 30405122, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine kinase 2
    Names
    Adk2-PA
    Adk2-PB
    Adk2-PC
    CG11255-PA
    CG11255-PB
    CG11255-PC
    adenosine kinase
    NP_001287054.1
    NP_648624.1
    NP_729863.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13019715..13022688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300125.1 → NP_001287054.1  adenosine kinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NZ5, Q9VU39
      Conserved Domains (2) summary
      PTZ00247
      Location:10 → 343
      PTZ00247; adenosine kinase; Provisional
      cl00192
      Location:14 → 343
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    2. NM_140367.4 → NP_648624.1  adenosine kinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NZ5, Q9VU39
      Related
      FBpp0075629
      Conserved Domains (2) summary
      PTZ00247
      Location:10 → 343
      PTZ00247; adenosine kinase; Provisional
      cl00192
      Location:14 → 343
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

    3. NM_168532.3 → NP_729863.1  adenosine kinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NZ5, Q9VU38
      Related
      FBpp0075630
      Conserved Domains (2) summary
      PTZ00247
      Location:10 → 343
      PTZ00247; adenosine kinase; Provisional
      cl00192
      Location:14 → 343
      ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NZ5 Q86NZ5
    Q9VU38 Q9VU38
    Q9VU39 Q9VU39

    Gene LinkOut

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