IntS8 Integrator 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: IntS8provided by FlyBase
Official Full Name: Integrator 8provided by FlyBase
Primary source: FLYBASE:FBgn0289323
Locus tag: Dmel_CG5859
See related: AllianceGenome:FB:FBgn0289323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5859; Dmel\CG5859; EG:EG0003.5; Int8; intS8; l(2)SH1314; l(2)SH2 1314
Summary: Involved in several processes, including negative regulation of BMP signaling pathway; positive regulation of neuron differentiation; and snRNA 3'-end processing. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16850437..16854104)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12737942..12741609)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.
Title: Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in snRNA 3'-end processing	IDA Inferred from Direct Assay more info	PubMed
involved_in snRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
involved_in snRNA processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of integrator complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed