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    CG12170 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12170provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037356
    Locus tag
    Dmel_CG12170
    See related
    AllianceGenome:FB:FBgn0037356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.367; Dmel\CG12170
    Summary
    Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12170 in Genome Data Viewer
    Location:
    83B7-83B7; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5637234..5638657)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1462956..1464379)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Metastasis associated 1-like Neighboring gene Secretory 23 Neighboring gene ethanol sensitive with low memory

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia. Yuan LL, et al. J Proteome Res, 2015 Sep 4. PMID 26220534
    2. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article
    3. Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy. Palozzi JM, et al. Cell Metab, 2022 Nov 1. PMID 36323236
    4. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    5. Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. Bonnay F, et al. EMBO J, 2014 Oct 16. PMID 25180232, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12170-PA
    NP_649565.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5637234..5638657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141308.3 → NP_649565.1  uncharacterized protein Dmel_CG12170 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGI4, Q9VNF5
      Related
      FBpp0078358
      Conserved Domains (2) summary
      PRK07314
      Location:23 → 437
      PRK07314; 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
      cd00834
      Location:24 → 434
      KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGI4 Q8IGI4
    Q95SJ9 Q95SJ9
    Q9VNF5 Q9VNF5

    Gene LinkOut

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