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    Vps26 Vacuolar protein sorting 26 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31144, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vps26provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 26provided by FlyBase
    Primary source
    FLYBASE:FBgn0014411
    Locus tag
    Dmel_CG14804
    See related
    AllianceGenome:FB:FBgn0014411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    131F2S; anon-sts13; CG14804; Dmel\CG14804; DmVps26; dvps26; dVps26; Dvps26; EG:63B12.8; ESTS:131F2S; vps26; VPS26
    Summary
    Enables cargo receptor activity. Involved in endosome to plasma membrane protein transport and regulation of Wnt signaling pathway. Part of retromer complex. Is expressed in adult head; adult heart; and photoreceptor neurons. Used to study brain cancer. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to several human genes including VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Vps26 in Genome Data Viewer
    Location:
    2B13-2B13; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1873853..1876474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1767886..1770507)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 18 Neighboring gene Peroxin 5 Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase assembly factor 8 Neighboring gene trithorax-related

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endosome to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of retromer complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of retromer, cargo-selective complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    vacuolar protein sorting 26
    Names
    CG14804-PA
    Vps26-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1873853..1876474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130596.3NP_569952.2  vacuolar protein sorting 26 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46088, Q4QQB4, Q95SD6, Q9W552
      Related
      FBpp0070298
      Conserved Domains (1) summary
      pfam03643
      Location:6280
      Vps26; Vacuolar protein sorting-associated protein 26