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    ogre optic ganglion reduced [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ogreprovided by FlyBase
    Official Full Name
    optic ganglion reducedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004646
    Locus tag
    Dmel_CG3039
    See related
    AllianceGenome:FB:FBgn0004646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cb-8; CB8; CG3039; Dm-inx1; Dmel\CG3039; FBpp0070995; inx-1; inx1; Inx1; jnL3; l(1)6Ec; l(1)jnL3; l(1)ogre; Ogre
    Summary
    Predicted to enable gap junction channel activity. Involved in phototransduction, visible light. Located in basolateral plasma membrane and gap junction. Is expressed in several structures, including adult head; clypeo-labral primordium; epithelium; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ogre in Genome Data Viewer
    Location:
    6E4-6E4; 1-18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6973620..6991318, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6867653..6885351, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44084 Neighboring gene boudin Neighboring gene Innexin 7 Neighboring gene long non-coding RNA:CR43837

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The l(1)ogre gene of Drosophila melanogaster is expressed in postembryonic neuroblasts. Watanabe T, et al. Dev Biol, 1992 Jul. PMID 1628755
    2. Poly(dC) segments and cloning artifacts in databases. Paricio N, et al. Genetics, 1995 Jan. PMID 7705649, Free PMC Article
    3. Analysis of a cDNA from the neurologically active locus shaking-B (Passover) of Drosophila melanogaster. Crompton DE, et al. Gene, 1992 Dec 15. PMID 1487155
    4. Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system. Holcroft CE, et al. J Cell Sci, 2013 Sep 1. PMID 23813964
    5. Gastrointestinal development in the Drosophila embryo requires the activity of innexin gap junction channel proteins. Bauer R, et al. Cell Commun Adhes, 2001. PMID 12064608

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of either ogre or inx2 selectively in glia, by targeted expression of RNA interference transgenes, leads to a significant reduction in the size of the larval nervous system and behavioural defects in surviving adults.
      Title: Innexins Ogre and Inx2 are required in glial cells for normal postembryonic development of the Drosophila central nervous system.
    2. Data propose that Inx3 is a critical factor for dorsal closure and that it mediates the stability of Inx1, 2 and DE-cadherin by forming a complex.
      Title: Innexin 3, a new gene required for dorsal closure in Drosophila embryo.
    3. innexin 1 predominantly localized to the baso-lateral domain of follicle cells.
      Title: Gap junctions in the ovary of Drosophila melanogaster: localization of innexins 1, 2, 3 and 4 and evidence for intercellular communication via innexin-2 containing channels.
    4. Data show that innexins, including shakB and ogre, are not functionally interchangeable in Drosophila during photoreceptor development.
      Title: Gap junction proteins are not interchangeable in development of neural function in the Drosophila visual system.
    5. role of the innexin 2 and ogre genes during gastrointestinal development of the fly embryo
      Title: Gastrointestinal development in the Drosophila embryo requires the activity of innexin gap junction channel proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intercellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction, visible light IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in visual behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    optic ganglion reduced
    Names
    CG3039-PA
    CG3039-PB
    CG3039-PC
    CG3039-PD
    CG3039-PE
    CG3039-PF
    contrast-blind-8
    innexin 1
    innexin-1
    ogre-PA
    ogre-PB
    ogre-PC
    ogre-PD
    ogre-PE
    ogre-PF
    optic ganglia-reduced

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6973620..6991318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258628.3 → NP_001245557.1  optic ganglion reduced, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin

    2. NM_001258629.2 → NP_001245558.1  optic ganglion reduced, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245558.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin

    3. NM_001272371.1 → NP_001259300.1  optic ganglion reduced, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259300.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin

    4. NM_080085.5 → NP_524824.1  optic ganglion reduced, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524824.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Related
      FBpp0070995
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin

    5. NM_167101.3 → NP_727147.1  optic ganglion reduced, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Related
      FBpp0070996
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin

    6. NM_001272370.1 → NP_001259299.1  optic ganglion reduced, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259299.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27716, Q0KHV4, Q9W3T8
      UniProtKB/TrEMBL
      M9PGW0
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 351
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGW0 M9PGW0
    P27716.1 P27716

    Gene LinkOut

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