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    Hn Henna [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnprovided by FlyBase
    Official Full Name
    Hennaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001208
    Locus tag
    Dmel_CG7399
    See related
    AllianceGenome:FB:FBgn0001208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bu; CG7399; Dmel\CG7399; DTPH; DTPHu; pah; Pah; PAH; Tph; TpH; TPH; Trh; TRH
    Summary
    Enables phenylalanine 4-monooxygenase activity and tryptophan 5-monooxygenase activity. Involved in several processes, including aromatic amino acid metabolic process; dopamine biosynthetic process; and long-term memory. Is expressed in several structures, including aminergic neurons; brain; ellipsoid body; embryonic/larval fat body; and head. Used to study phenylketonuria. Human ortholog(s) of this gene implicated in intellectual disability and phenylketonuria. Orthologous to human PAH (phenylalanine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    66A12-66A12; 3-21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7760453..7763166)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7753553..7756266)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Clock Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative study of Drosophila phenylalanine hydroxylase with a natural and a synthetic tetrahydropterin as cofactor. Bel Y, et al. Comp Biochem Physiol B, 1992 Nov. PMID 1458831
    2. Structure of the phenylalanine hydroxylase gene in Drosophila melanogaster and evidence of alternative promoter usage. Ruiz-Vázquez P, et al. Biochem Biophys Res Commun, 1996 Aug 5. PMID 8769124
    3. Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the insertion of a B104/roo transposable element in the Henna locus. Ruiz-Vázquez P, et al. Insect Biochem Mol Biol, 1999 Apr. PMID 10333570
    4. Commensal bacteria and essential amino acids control food choice behavior and reproduction. Leitão-Gonçalves R, et al. PLoS Biol, 2017 Apr. PMID 28441450, Free PMC Article
    5. The quantitative relations between variation in red eye pigment and related pteridine compounds in Drosophila melanogaster. Barthelmess IB, et al. Genet Res, 1970 Feb. PMID 5415228

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine 4-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine 4-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phenylalanine 4-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine 4-monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tryptophan 5-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tryptophan 5-monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-phenylalanine catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in L-phenylalanine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dopamine biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in eye pigment biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of germ-band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process from tryptophan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    henna
    Names
    CG7399-PA
    CG7399-PB
    CG7399-PC
    CG7399-PD
    Hn-PA
    Hn-PB
    Hn-PC
    Hn-PD
    Phenylalanine-hydroxylase
    brunette
    phenylalanine hydroxylase
    phenylalanine-tryptophan hydroxylase
    tryptophan hydrolase
    tryptophan hydroxylase
    NP_001014573.1
    NP_001261542.1
    NP_001261543.1
    NP_523963.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7760453..7763166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079239.4 → NP_523963.2  henna, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523963.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46110, P17276, Q27599, Q27600
      UniProtKB/TrEMBL
      B0LQU2, M9PBV1
      Related
      FBpp0076523
      Conserved Domains (3) summary
      TIGR01268
      Location:15 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
      cd04904
      Location:32 → 107
      ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
      pfam00351
      Location:118 → 447
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    2. NM_001274614.1 → NP_001261543.1  henna, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261543.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH57
      Conserved Domains (1) summary
      cl01244
      Location:1 → 173
      arom_aa_hydroxylase; Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan ...

    3. NM_001274613.1 → NP_001261542.1  henna, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46110, P17276, Q27599, Q27600
      UniProtKB/TrEMBL
      B0LQU2, M9PBV1
      Conserved Domains (3) summary
      TIGR01268
      Location:15 → 451
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
      cd04904
      Location:32 → 107
      ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
      pfam00351
      Location:118 → 447
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    4. NM_001014573.2 → NP_001014573.1  henna, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0IN41, Q59E23
      Conserved Domains (3) summary
      TIGR01268
      Location:10 → 446
      Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
      cd04904
      Location:27 → 102
      ACT_AAAH; ACT domain of the nonheme iron-dependent, aromatic amino acid hydroxylases (AAAH)
      pfam00351
      Location:113 → 442
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E8NH57 E8NH57
    M9PBV1 M9PBV1
    P17276.3 P17276
    Q59E23 Q59E23

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