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    RhoGAP68F Rho GTPase activating protein at 68F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP68Fprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 68Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036257
    Locus tag
    Dmel_CG6811
    See related
    AllianceGenome:FB:FBgn0036257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 6811; CG6811; Dmel\CG6811; RhoGAP
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including imaginal disc-derived leg morphogenesis; negative regulation of stress fiber assembly; and positive regulation of synaptic assembly at neuromuscular junction. Located in early endosome and recycling endosome. Is expressed in several structures, including embryonic hindgut; embryonic/larval dorsal vessel; ganglia; indirect flight muscle cell; and organism subdivision. Orthologous to several human genes including ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP68F in Genome Data Viewer
    Location:
    68F5-68F6; 3-38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12138868..12143380)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12131968..12136480)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Autophagy-related 12 Neighboring gene eukaryotic translation initiation factor 3 subunit l Neighboring gene Neurexin IV Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Rho GTPase-Activating Protein RhoGAP68F. Nahm M, et al. Exp Neurobiol, 2011 Mar. PMID 22110359, Free PMC Article
    2. Drosophila RhoGAP68F is a putative GTPase activating protein for RhoA participating in gastrulation. Sanny J, et al. Dev Genes Evol, 2006 Sep. PMID 16609869
    3. RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs. de Madrid BH, et al. Dev Biol, 2015 Mar 15. PMID 25617722, Free PMC Article
    4. Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila. McGurk L, et al. Hum Mol Genet, 2012 Jan 1. PMID 21949352, Free PMC Article
    5. Cross-talk between Rho and Rac GTPases drives deterministic exploration of cellular shape space and morphological heterogeneity. Sailem H, et al. Open Biol, 2014 Jan 22. PMID 24451547, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs.
      Title: RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endocytic recycling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventral furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 68F
    Names
    CG6811-PA
    CG6811-PC
    CG6811-PD
    CG6811-PE
    CG6811-PF
    RhoGAP68F-PA
    RhoGAP68F-PC
    RhoGAP68F-PD
    RhoGAP68F-PE
    RhoGAP68F-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12138868..12143380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001414142.1 → NP_001401037.1  Rho GTPase activating protein at 68F, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y8

    2. NM_001274814.1 → NP_001261743.1  Rho GTPase activating protein at 68F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAN9
      Conserved Domains (2) summary
      cd00170
      Location:48 → 176
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cd04404
      Location:212 → 407
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

    3. NM_140295.3 → NP_648552.1  Rho GTPase activating protein at 68F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTU3
      UniProtKB/TrEMBL
      M9PC96
      Related
      FBpp0075729
      Conserved Domains (2) summary
      cd00170
      Location:105 → 233
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cd04404
      Location:269 → 464
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

    4. NM_001274816.1 → NP_001261745.1  Rho GTPase activating protein at 68F, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEY9
      Conserved Domains (2) summary
      cd00170
      Location:104 → 232
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cd04404
      Location:268 → 463
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...

    5. NM_001274815.1 → NP_001261744.1  Rho GTPase activating protein at 68F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261744.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VTU3
      UniProtKB/TrEMBL
      M9PC96
      Conserved Domains (2) summary
      cd00170
      Location:105 → 233
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      cd04404
      Location:269 → 464
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F0JAN9 F0JAN9
    M9PC96 M9PC96
    M9PEY9 M9PEY9
    Q9VTU3.1 Q9VTU3

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