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    e(r) enhancer of rudimentary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    e(r)provided by FlyBase
    Official Full Name
    enhancer of rudimentaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011586
    Locus tag
    Dmel_CG1871
    See related
    AllianceGenome:FB:FBgn0011586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1871; Dmel\CG1871; ER; ER_DROME
    Summary
    Located in nucleus. Is expressed in nurse cell and organism. Orthologous to human ERH (ERH mRNA splicing and mitosis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See e(r) in Genome Data Viewer
    Location:
    8B7-8B7; 1-25 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8904144..8906248, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8798177..8800281, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen III synthase 1 Neighboring gene RNA-binding motif protein 13 Neighboring gene long non-coding RNA:CR44111 Neighboring gene retinal degeneration A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thirty Years with ERH: An mRNA Splicing and Mitosis Factor Only or Rather a Novel Genome Integrity Protector? Kozlowski P. Cells, 2023 Oct 13. PMID 37887293, Free PMC Article
    2. The generation and analysis of deficiencies within a small genomic region on the X chromosome of Drosophila melanogaster containing two genes, enhancer of rudimentary and CG15352. Roykhman M, et al. Fly (Austin), 2007 Jul-Aug. PMID 18820471
    3. Drosophila Enhancer of Rudimentary Homolog, ERH, Is a Binding Partner of RPS3, RPL19, and DDIT4, Suggesting a Mechanism for the Nuclear Localization of ERH. Tsubota SI, et al. Mol Biol Int, 2016. PMID 27830090, Free PMC Article
    4. Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene. Wojcik E, et al. Genetics, 1994 Dec. PMID 7896098, Free PMC Article
    5. Regulation of the Drosophila melanogaster protein, enhancer of rudimentary, by casein kinase II. Gelsthorpe ME, et al. Genetics, 2006 Sep. PMID 16849599, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ER is localized to the developing CNS and has a role in the Notch signaling pathway.
      Title: Interactions between enhancer of rudimentary and Notch and deltex reveal a regulatory function of enhancer of rudimentary in the Notch signaling pathway in Drosophila melanogaster.
    2. Deficiencies of e(r) enhance the mutant wing phenotype of a hypomorphic rudimentary allele, r(hd1; The expression of e(r) in the nurse cells of the ovary is consistent with the low fertility, and suggests an ovarian function for e(r).
      Title: The generation and analysis of deficiencies within a small genomic region on the X chromosome of Drosophila melanogaster containing two genes, enhancer of rudimentary and CG15352.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enhancer of rudimentary
    Names
    CG1871-PA
    CG1871-PB
    CG1871-PC
    CG1871-PD
    CG1871-PE
    e(r)-PA
    e(r)-PB
    e(r)-PC
    e(r)-PD
    e(r)-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8904144..8906248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167171.2 → NP_727293.1  enhancer of rudimentary, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V463, Q24337, Q9W3B1
      UniProtKB/TrEMBL
      M9PJE8
      Related
      FBpp0071210
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary

    2. NM_001272435.1 → NP_001259364.1  enhancer of rudimentary, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259364.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V463, Q24337, Q9W3B1
      UniProtKB/TrEMBL
      M9PJE8
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary

    3. NM_001272434.1 → NP_001259363.1  enhancer of rudimentary, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V463, Q24337, Q9W3B1
      UniProtKB/TrEMBL
      M9PJE8
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary

    4. NM_001272436.1 → NP_001259365.1  enhancer of rudimentary, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V463, Q24337, Q9W3B1
      UniProtKB/TrEMBL
      M9PJE8
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary

    5. NM_079923.3 → NP_524662.1  enhancer of rudimentary, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V463, Q24337, Q9W3B1
      UniProtKB/TrEMBL
      M9PJE8
      Related
      FBpp0071209
      Conserved Domains (1) summary
      pfam01133
      Location:2 → 99
      ER; Enhancer of rudimentary
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PJE8 M9PJE8
    Q24337.1 Q24337

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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