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    Map205 Microtubule-associated protein 205 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map205provided by FlyBase
    Official Full Name
    Microtubule-associated protein 205provided by FlyBase
    Primary source
    FLYBASE:FBgn0002645
    Locus tag
    Dmel_CG1483
    See related
    AllianceGenome:FB:FBgn0002645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    205-kDa MAP; 205K MAP; 205kD MAP; 205kDa MAP; CG1483; Dmel\CG1483; map205; MAP205; MAP4
    Summary
    Involved in centrosome cycle and mitotic cell cycle. Located in midbody and spindle. Part of microtubule associated complex. Is expressed in several structures, including adult head; adult heart; brain; larval somatic muscle cell; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Map205 in Genome Data Viewer
    Location:
    100F2-100F4; 3-103 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (32055279..32068441, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27881001..27894163, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene kurtz Neighboring gene modulo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of structure and microtubule assembly activity of the Drosophila 205K MAP. Irminger-Finger I, et al. Biol Chem, 1998 Nov. PMID 9865614
    2. Stable expression of heterologous microtubule-associated proteins (MAPs) in Chinese hamster ovary cells: evidence for differing roles of MAPs in microtubule organization. Barlow S, et al. J Cell Biol, 1994 Aug. PMID 7519616, Free PMC Article
    3. A microtubule-associated protein in Drosophila melanogaster: identification, characterization, and isolation of coding sequences. Goldstein LS, et al. J Cell Biol, 1986 Jun. PMID 3086324, Free PMC Article
    4. Analysis of the primary sequence and microtubule-binding region of the Drosophila 205K MAP. Irminger-Finger I, et al. J Cell Biol, 1990 Dec. PMID 1703540, Free PMC Article
    5. Identification of ubiquitous high-molecular-mass, heat-stable microtubule-associated proteins (MAPs) that are related to the Drosophila 205-kDa MAP but are not related to the mammalian MAP-4. Kimble M, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1502185, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
      Title: Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis.
    2. Report the 2.3-A crystal structure of the complex of the Danio rerio PLK1 N-terminal kinase domain (KD) and a C-terminal Polo-box domain (PBD) together with a PBD-binding motif of microtubule-associated protein 205 (Map205(PBM)).
      Title: Structural basis for the inhibition of Polo-like kinase 1.
    3. Map205-dependent targeting of Polo to microtubules provides a stable reservoir of Polo that can be rapidly mobilized by the activity of Cdk1 at mitotic entry.
      Title: Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c32062696-32062636 mobile_element_type = transposon:Ivk{}4073
    • Loc: c32064740-32064332 mobile_element_type = transposon:INE-1{}4021

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Microtubule-associated protein 205
    Names
    CG1483-PA
    CG1483-PB
    CG1483-PC
    Map205-PA
    Map205-PB
    Map205-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      32055279..32068441 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276225.1 → NP_001263154.1  Microtubule-associated protein 205, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23226, Q53YG1, Q9V9S1
      UniProtKB/TrEMBL
      A0A0B4KI71
      Conserved Domains (2) summary
      PHA03255
      Location:709 → 866
      PHA03255; BDLF3; Provisional
      pfam03035
      Location:809 → 937
      RNA_capsid; Calicivirus putative RNA polymerase/capsid protein

    2. NM_170586.2 → NP_733465.1  Microtubule-associated protein 205, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23226, Q53YG1, Q9V9S1
      UniProtKB/TrEMBL
      Q8IMF5
      Related
      FBpp0085235
      Conserved Domains (2) summary
      PHA03255
      Location:785 → 942
      PHA03255; BDLF3; Provisional
      pfam03035
      Location:885 → 1013
      RNA_capsid; Calicivirus putative RNA polymerase/capsid protein

    3. NM_079876.3 → NP_524615.1  Microtubule-associated protein 205, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524615.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23226, Q53YG1, Q9V9S1
      Related
      FBpp0085234
      Conserved Domains (2) summary
      PHA03255
      Location:763 → 920
      PHA03255; BDLF3; Provisional
      pfam03035
      Location:863 → 991
      RNA_capsid; Calicivirus putative RNA polymerase/capsid protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI71 A0A0B4KI71
    P23226.2 P23226
    Q8IMF5 Q8IMF5

    Gene LinkOut

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