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    wcd wicked [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wcdprovided by FlyBase
    Official Full Name
    wickedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262560
    Locus tag
    Dmel_CG7989
    See related
    AllianceGenome:FB:FBgn0262560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7989; Dmel\CG7989; l(2)k07824; l(2)kO7824; Wcd
    Summary
    Involved in female germ-line stem cell asymmetric division; neuroblast proliferation; and rRNA processing. Located in germinal vesicle and nucleolus. Part of small nuclear ribonucleoprotein complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; mesoderm; and visceral muscle primordium. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wcd in Genome Data Viewer
    Location:
    53C1-53C1; 2-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16345838..16347500, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12233343..12235005, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of stage-specific germ cells using FACS in Drosophila germarium. Vallés AM, et al. Methods Cell Biol, 2020. PMID 32423645
    2. Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Fichelson P, et al. Nat Cell Biol, 2009 Jun. PMID 19430468
    3. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
    4. Large clusters of co-expressed genes in the Drosophila genome. Boutanaev AM, et al. Nature, 2002 Dec 12. PMID 12478293
    5. A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis. Jagut M, et al. G3 (Bethesda), 2013 Mar. PMID 23450845, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in female germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small nuclear ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    wicked
    Names
    CG7989-PA
    lethal (2) k07824
    wcd-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16345838..16347500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137277.4 → NP_611121.1  wicked [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611121.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V7P1
      Related
      FBpp0086314
      Conserved Domains (3) summary
      COG2319
      Location:131 → 444
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:298 → 332
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:296 → 504
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V7P1.1 Q9V7P1

    Gene LinkOut

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