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    brwl brickwall [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brwlprovided by FlyBase
    Official Full Name
    brickwallprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032130
    Locus tag
    Dmel_CG3838
    See related
    AllianceGenome:FB:FBgn0032130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.445; bs09e08.y1; CC20; CG3838; Dmel\CG3838; NEST:bs09e08
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; cuboidal/columnar epithelium; gut section; head epidermis primordium; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See brwl in Genome Data Viewer
    Location:
    30B12-30B12; 2-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9568890..9573572)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9568890..9573572)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene junctophilin Neighboring gene long non-coding RNA:CR44149 Neighboring gene Mitochondrial trifunctional protein alpha subunit Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43621 Neighboring gene glial cells missing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Drosophila melanogaster Chromatin Landscape and Its Associated Proteins. Parey E, et al. Genome Biol Evol, 2019 Mar 1. PMID 30689829, Free PMC Article
    2. Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila. Shukla V, et al. G3 (Bethesda), 2018 May 31. PMID 29669801, Free PMC Article
    3. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Andrioli LP, et al. Development, 2002 Nov. PMID 12397102
    4. The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist. Bhaskar V, et al. Gene, 2002 Oct 16. PMID 12459265
    5. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Claycomb JM, et al. Dev Cell, 2004 Jan. PMID 14723854

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. brwl and stwl likely share a common MADF-BESS ancestor and they are expressed in overlapping spatiotemporal domains to ensure robust development of the female germline.
      Title: Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    brickwall
    Names
    CG3838-PA
    CG3838-PB
    brwl-PA
    brwl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9568890..9573572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164859.2 → NP_723469.1  brickwall, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T091, Q9VLA6
      Related
      FBpp0079432
      Conserved Domains (2) summary
      smart00595
      Location:60 → 145
      MADF; subfamily of SANT domain
      pfam02944
      Location:356 → 389
      BESS; BESS motif

    2. NM_135454.5 → NP_609298.1  brickwall, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T091, Q9VLA6
      Related
      FBpp0079433
      Conserved Domains (2) summary
      smart00595
      Location:60 → 145
      MADF; subfamily of SANT domain
      pfam02944
      Location:356 → 389
      BESS; BESS motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T091 Q8T091
    Q9VLA6 Q9VLA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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