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    MTA1-like Metastasis associated 1-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTA1-likeprovided by FlyBase
    Official Full Name
    Metastasis associated 1-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027951
    Locus tag
    Dmel_CG2244
    See related
    AllianceGenome:FB:FBgn0027951
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2244; Dmel\CG2244; dMTA; dMTA-1; dMTA1-like; MTA; MTA-1like; MTA-like; MTA1; p120
    Summary
    Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in chromosome condensation. Located in nucleoplasm. Part of NuRD complex. Is expressed in adult brain cell body rind; organism; primordial germ cell; and spermatozoon. Orthologous to several human genes including MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MTA1-like in Genome Data Viewer
    Location:
    83B7-83B7; 3-47.5 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5638655..5648738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1464377..1474460, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Secretory 23 Neighboring gene ethanol sensitive with low memory

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2. Marhold J, et al. BMC Mol Biol, 2004 Oct 29. PMID 15516265, Free PMC Article
    2. Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. Lenz J, et al. PLoS Genet, 2021 Feb. PMID 33600407, Free PMC Article
    3. A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Ballestar E, et al. Eur J Biochem, 2001 Oct. PMID 11606202
    4. Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex. Alqarni SS, et al. J Biol Chem, 2014 Aug 8. PMID 24920672, Free PMC Article
    5. Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex. Demirdizen E, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31713634, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metastasis associated 1-like
    Names
    CG2244-PA
    CG2244-PB
    CG2244-PC
    CG2244-PD
    MTA-like
    MTA1-like-PA
    MTA1-like-PB
    MTA1-like-PC
    MTA1-like-PD
    metastasis-associated-1-like-protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5638655..5648738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144539.2 → NP_001138011.1  metastasis associated 1-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0T5, Q6AWS2
      Conserved Domains (5) summary
      smart00717
      Location:326 → 371
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:325 → 370
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      cd00202
      Location:431 → 481
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:19 → 226
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:205 → 257
      ELM2; ELM2 domain

    2. NM_141309.4 → NP_649566.2  metastasis associated 1-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649566.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWS2, Q9VNF7
      Related
      FBpp0078383
      Conserved Domains (5) summary
      smart00717
      Location:317 → 362
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:316 → 361
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      cd00202
      Location:422 → 472
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 217
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:196 → 248
      ELM2; ELM2 domain

    3. NM_169086.3 → NP_730976.1  metastasis associated 1-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730976.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U6X3, Q9VNF6
      Related
      FBpp0078382
      Conserved Domains (5) summary
      smart00717
      Location:353 → 398
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:352 → 397
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      cd00202
      Location:458 → 508
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 253
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:232 → 284
      ELM2; ELM2 domain

    4. NM_001275364.2 → NP_001262293.1  metastasis associated 1-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG70, Q9U6X3
      Conserved Domains (5) summary
      smart00717
      Location:353 → 398
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:352 → 397
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      cd00202
      Location:458 → 508
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      cd04709
      Location:3 → 253
      BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
      pfam01448
      Location:232 → 284
      ELM2; ELM2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG70 A0A0B4KG70
    B7Z0T5 B7Z0T5
    Q6AWS2 Q6AWS2
    Q95RR0 Q95RR0
    Q95TP6 Q95TP6
    Q9U6X3 Q9U6X3
    Q9VNF6 Q9VNF6
    Q9VNF7 Q9VNF7

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