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    tzn tenzing norgay [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tznprovided by FlyBase
    Official Full Name
    tenzing norgayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037024
    Locus tag
    Dmel_CG4365
    See related
    AllianceGenome:FB:FBgn0037024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4365; Dmel\CG4365
    Summary
    Predicted to enable hydroxyacylglutathione hydrolase activity. Involved in response to hypoxia. Predicted to be located in mitochondrial matrix. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tzn in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20798645..20800081)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20791745..20793181)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43706 Neighboring gene uncharacterized protein Neighboring gene Spc105-related Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. Trinh K, et al. J Neurosci, 2008 Jan 9. PMID 18184789, Free PMC Article
    2. Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase. Muñoz-Soriano V, et al. J Mol Neurosci, 2012 Sep. PMID 22562816
    3. Intrakinetochore localization and essential functional domains of Drosophila Spc105. Schittenhelm RB, et al. EMBO J, 2009 Aug 19. PMID 19590494, Free PMC Article
    4. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
    5. Quantitative Proteomic Analyses of Molecular Mechanisms Associated with Cytoplasmic Incompatibility in Drosophila melanogaster Induced by Wolbachia. Yuan LL, et al. J Proteome Res, 2015 Sep 4. PMID 26220534

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydroxyacylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tenzing norgay
    Names
    CG4365-PA
    CG4365-PB
    CG4365-PC
    tzn-PA
    tzn-PB
    tzn-PC
    NP_649258.1
    NP_730568.1
    NP_730569.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20798645..20800081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168874.2 → NP_730569.1  tenzing norgay, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7P8
      Related
      FBpp0077910
      Conserved Domains (3) summary
      PLN02469
      Location:13 → 270
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:187 → 267
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:16 → 186
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    2. NM_168873.2 → NP_730568.1  tenzing norgay, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730568.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUD4, Q8IPU3
      Related
      FBpp0077912
      Conserved Domains (3) summary
      PLN02469
      Location:90 → 347
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:264 → 344
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:93 → 263
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    3. NM_141001.2 → NP_649258.1  tenzing norgay, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUD4, Q9VPB3
      Related
      FBpp0077911, FBtr0078253
      Conserved Domains (3) summary
      PLN02469
      Location:47 → 304
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:221 → 301
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:50 → 220
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPU3 Q8IPU3
    Q9I7P8 Q9I7P8
    Q9VPB3 Q9VPB3

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