ND-42 NADH dehydrogenase (ubiquinone) 42 kDa subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-42provided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 42 kDa subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0019957
Locus tag: Dmel_CG6343
See related: AllianceGenome:FB:FBgn0019957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A10; CG6343; Dmel\CG6343; dNDUFA10; ND42; NdufA10; NDUFA10; NUDM
Summary: Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; larval muscle cell; and mesoderm. Used to study Leigh disease. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94A1-94A1; 3-74 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22027709..22029393)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17853431..17855115)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell RNA-sequencing reveals the transcriptional landscape of ND-42 mediated spermatid elongation via mitochondrial derivative maintenance in Drosophila testes.
Title: Single-cell RNA-sequencing reveals the transcriptional landscape of ND-42 mediated spermatid elongation via mitochondrial derivative maintenance in Drosophila testes.
Our findings support the emerging view that PINK1 plays a role in regulating complex I activity separate from its role with Parkin in mitophagy
Title: The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NADH dehydrogenase (ubiquinone) 42 kDa subunit

Names: CG6343-PA; CG6343-PB; CG6343-PC; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10; NADH ubiquinone oxidoreductase 42 kDa; NADH-ubiquinone oxidoreductase 42 kDa subunit; NADH-ubiquinone oxidoreductase subunit; NADH: UBIQUINONE REDUCTASE 42 KD SUBUNIT PRECURSOR; NADH:ubiquinone oxidoreductase 42 kDa subunit; NADH:ubiquinone reductase 42 kD; NADH:ubiquinone reductase 42kD subunit precursor; ND-42-PA; ND-42-PB; ND-42-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22027709..22029393

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169990.3 → NP_732692.1 NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732692.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91929, Q9VD54

UniProtKB/TrEMBL

A4V383

Related

FBpp0083571

Conserved Domains (1) summary

cd02030
Location:84 → 308

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
NM_001275892.1 → NP_001262821.1 NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91929, Q9VD54

UniProtKB/TrEMBL

A4V383

Conserved Domains (1) summary

cd02030
Location:84 → 308

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...
NM_079721.4 → NP_524445.1 NADH dehydrogenase (ubiquinone) 42 kDa subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91929, Q9VD54

UniProtKB/TrEMBL

A4V383

Related

FBpp0083570

Conserved Domains (1) summary

cd02030
Location:84 → 308

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...